4596-45-6Relevant academic research and scientific papers
A mild and efficient method for the preparation of acyl azides from carboxylic acids using triphosgene
Gumaste,Bhawal,Deshmukh
, p. 1345 - 1346 (2002)
An efficient use of triphosgene for the preparation of various acyl azides from carboxylic acids and sodium azide is described.
FeCl36H2O-Catalyzed acceleration of the acylation of sodium azide with n-acylbenzotriazoles
Zhong, Zhiyun,Hu, Jieling,Wang, Xiaoxia,Liu, Junhua,Zhang, Longfeng
experimental part, p. 2461 - 2467 (2011/08/05)
Catalyzed by ferric chloride hexahydrate (FeCl36H2O), the acylation of sodium azide with N-acylbenzotriazoles was greatly accelerated in a mixed solvent of acetone and water. Thus, good to excellent yields of a variety of acyl azides were obtained at room temperature in a short time. Furthermore, because of the complete conversion of N-acylbenzotriazoles and the easy removal of the by-product, purification by column chromatography was no longer required, which made the protocol suitable for large-scale preparation.
Direct synthesis of acyl azides from carboxylic acids using 2-azido-l,3-dimethylimidazolinium chloride
Kitamura, Mitsuru,Tashiro, Norifumi,Takamoto, Yusuke,Okauchi, Tatsuo
scheme or table, p. 731 - 733 (2011/01/08)
Acyl azides were directly synthesized from carboxylic acids by the treatment with 2-azido-l,3-dimethylimidazolinium chloride (ADMC, 1) and amine. This procedure resulted in acyl azides in good yields and was applied to the amidation of amino acid derivatives without racemization of the products.
