45966-19-6

Usage

Uses

Used in Dye and Pigment Production:
4-[(ethylamino)methyl]phenol is used as an intermediate in the production of various dyes and pigments, contributing to the development of a wide range of colorants for different applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-[(ethylamino)methyl]phenol is utilized for the synthesis of certain medications, playing a crucial role in the development of new drugs and therapeutic agents.
Used as a pH Indicator:
4-[(ethylamino)methyl]phenol is employed as a pH indicator, allowing for the measurement and monitoring of acidity or alkalinity in various chemical and biological processes.
Used in Hair Dye Production:
This chemical compound is also used in the production of hair dyes, providing a wide range of color options and enhancing the performance of hair coloring products.
Safety Precautions:
Due to its potential hazards, it is essential to follow safety precautions when handling and using 4-[(ethylamino)methyl]phenol. Proper protective equipment, storage, and disposal methods should be implemented to ensure the safety of individuals and the environment.

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 80767-12-0 4-hydroxybenzyl acetate 
• 75-04-7 ethylamine 

Relevant academic research and scientific papers

Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase

Soman is a highly toxic nerve agent with strong inhibition of acetylcholinesterase (AChE), but of the few reactivators showing antidotal efficiency for soman-inhibited AChE presently are all permanently charged cationic oximes with poor penetration of the blood-brain barrier. To overcome this problem, uncharged reactivators have been designed and synthesized, but few of them were efficient for treating soman poisoning. Herein, we used a dual site biding strategy to develop more efficient uncharged reactivators. The ortho-hydroxylbenzaldoximes were chosen as reactivation ligands of AChE to prevent the secondary poisoning of AChE, and simple aromatic groups were used as peripheral site ligands of AChE, which were linked to the oximes in a similar way as that found in the reactivator HI-6. The in vitro experiment demonstrated that some of the resulting conjugates have robust activity against soman-inhibited AChE, and oxime 8b was highlighted as the most efficient one. Although not good as HI-6 in vitro, these new compounds hold promise for development of more efficient centrally acting reactivators for soman poisoning due to their novel nonquaternary structures, which are predicted to be able to cross the blood-brain barrier.

SULFONYLAMINO-ACETIC ACID DERIVATIVES

The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

REACTIVITY OF NEW PRECURSORS OF QUINONE METHIDES

The azidomethylene protecting group allows the synthesis of unstable phenolic compounds which are used as quinone methide precursors in the alkylations of alcohols, phenols, azide, thiophenol, amines, enols and enolates.