459872-39-0Relevant articles and documents
Hydroxamic acid derivatives of 3-Phenyl propionic acids useful as therapeutic agents for treating anthrax poisoning
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Page/Page column 17-18, (2008/12/07)
Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3-phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists
Gardner, Daniel S.,Santella III, Joseph B.,Tebben, Andrew J.,Batt, Douglas G.,Ko, Soo S.,Traeger, Sarah C.,Welch, Patricia K.,Wadman, Eric A.,Davies, Paul,Carter, Percy H.,Duncia, John V.
, p. 586 - 595 (2008/09/17)
Conformational analysis of the 3-benzylpiperidine in CCR3 antagonist clinical candidate 1 (BMS-639623) predicts that the benzylpiperidine may be replaced by acyclic, conformationally stabilized, anti-1,2-disubstituted phenethyl- and phenpropylamines. Ab i
N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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, (2008/06/13)
The present application describes modulators of chemokine receptors of formula (I), or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
A new series of estrogen receptor modulators that display selectivity for estrogen receptor β
Henke, Brad R.,Consler, Thomas G.,Go, Ning,Hale, Ron L.,Hohman, Dana R.,Jones, Stacey A.,Lu, Amy T.,Moore, Linda B.,Moore, John T.,Orband-Miller, Lisa A.,Robinett, R. Graham,Shearin, Jean,Spearing, Paul K.,Stewart, Eugene L.,Turnbull, Philip S.,Weaver, Susan L.,Williams, Shawn P.,Wisely, G. Bruce,Lambert, Millard H.
, p. 5492 - 5505 (2007/10/03)
A series of 1,3,5-triazine-based estrogen receptor (ER) modulators that are modestly selective for the ERβ subtype are reported. Compound 1, which displayed modest potency and selectivity for ERβ vs ERα, was identified via high-throughput screening utiliz