4603-32-1

Basic information

• Product Name: threo-3-Hydroxy-2,3-diphenylpropionic acid
• Synonyms: threo-3-Hydroxy-2,3-diphenylpropionic acid
• CAS NO: 4603-32-1
• Molecular Weight: 242.274
• Mol File: 4603-32-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: threo-3-Hydroxy-2,3-diphenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: threo-3-Hydroxy-2,3-diphenylpropionic acid(4603-32-1)
• EPA Substance Registry System: threo-3-Hydroxy-2,3-diphenylpropionic acid(4603-32-1)

Safety Data

• Hazardous Substances Data: 4603-32-1(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 100-52-7 benzaldehyde 
• 114-70-5 sodium phenylacetate 
• 15082-44-7 dilithium phenyl acetic acid 
• 31491-21-1 2-phenyl-1,1-bis(trimethylsilyloxy)ethene 
• 920-39-8 isopropylmagnesium bromide 

Downstream Products

• 4250-02-6 1-diazo-3-phenyl-2-propanone 
• 108896-24-8 (2RS,3SR)-3-hydroxy-2,3-diphenyl-propionic acid hydrazide 
• 95135-80-1 (2RS,3RS)-2,3-dicyclohexyl-3-hydroxy-propionic acid-(2-diethylamino-ethyl ester); hydrochloride 
• 103-82-2 phenylacetic acid 
• 100-52-7 benzaldehyde 
• 17226-93-6 α-benzenessigsaeure-methylester 
• 645-49-8 cis-stilben 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 82575-09-5 (2R,3S)-3-Hydroxy-2,3-diphenyl-propionatetetramethyl-ammonium; 
• 342804-72-2 3,4-Diphenyl-oxetan-2-one 
• 92791-30-5 (2RS,3RS)-2,3-dicyclohexyl-3-hydroxy-propionic acid 
• 17226-93-6 (2R,3R)-und (2S,3S)-3-Hydroxy-2,3-diphenylpropansaeure-methylester 
• 14367-02-3 1,2-anti-1,2-Diphenylpropan-1,3-diol 

Relevant articles and documents

Formation and fragmentation of 4-diazo-1,2-diphenyl-3-oxo-butyl acetate

Threo-4-Diazo-1,2-diphenyl-3-oxo-butyl acetate (15) could be prepared via the classical route 6 → 8 → 10 → 12 → 13 → 15. However, its alkaline hydrolysis to the bifunctional hydroxy compound 17 led to a spontaneous dehydration to the diazoketone (E)-18 and to a fragmentation to acetic acid, benzaldehyde (8) and diazoketone 19.

Methoxide-promoted Elimination of Methyl threo 3-Halogeno- and Methyl threo and erythro 3-Acetoxy-2-aryl-3-phenylpropanoates

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STEREOSELECTIVE ADDITIONS TO CARBOXYLIC ACID DIANIONS AND β-LACTONE SUBSTITUTED ESTER ENOLATES. APPLICATION TO THE SYNTHESIS OF RACEMIC EPI-BLASTMYCINONE, δ-MULTISTRIATINE, PARACONIC ESTERS AND LIGNANTYPE DILACTONES

New stereoselective syntheses are reported for racemic 4-epi-blastmycinone (6) and δ-multistriatine (13) utilizing the anti-configurated γ,δ-unsaturated β-hydroxy-carboxylic acids 2a/b.A diastereo- and enantioselective aldoltype addition of phenylacetic acid dianion to benzaldehyde has been achaived by employing optically active alkoxide amide bases.Finally, highly stereocontrolled additions to the novel β-lactone substituted ester enolates 22 are described.