58137-79-4Relevant academic research and scientific papers
Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin
Rusch, Marion,Thevenon, Arnaud,Hoepfner, Dominic,Aust, Thomas,Studer, Christian,Patoor, Maude,Rollin, Patrick,Livendahl, Madeleine,Ranieri, Beatrice,Schmitt, Esther,Spanka, Carsten,Gademann, Karl,Bouchez, Laure C.
, p. 644 - 649 (2019)
Selective and specific inhibitors of Plasmodium falciparum lysyl-tRNA synthetase represent promising therapeutic antimalarial avenues. Cladosporin was identified as a potent P. falciparum lysyl-tRNA synthetase inhibitor, with an activity against parasite
Total Synthesis of the Resorcyclic Acid Lactone Spiroketal Citreoviranol
Quach, Rachelle,Furkert, Daniel. P.,Brimble, Margaret A.
, p. 8343 - 8350 (2016)
The first total synthesis of resorcyclic acid lactone spiroketal citreoviranol (1) is described. The synthesis was completed in nine steps and via Sonogashira cross-coupling, gold-catalyzed cyclization, and an unusual base-induced ketalization. The relati
A New Secondary Metabolite from Alternaria Alternata: Structure Elucidation and Total Synthesis of Altenuic Acid IV
Kohler, Dominik,Podlech, Joachim
, p. 1748 - 1753 (2019/02/20)
A putative intermediate in the biosynthesis of altenuic acids I–III was isolated from Alternaria alternata in the 1950ies and a sample survived over the decades. This resorcylic lactone named altenuic acid IV is a composite of a resorcylic and a muconic a
COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES
-
Page/Page column 30-31; 41-42, (2008/12/07)
The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.
Depsidone Synthesis. Part 21. A New Synthesis of Grisa-2',5'-diene-3,4'-diones
Sargent, Melvyn V.
, p. 403 - 411 (2007/10/02)
Treatment of suitably substituted methyl 2-phenoxybenzoates with titanium(IV) chloride and dry hydrogen chloride afforded grisa-2',5'-diene-3,4'-diones in high yield.The structures of these compounds followed from their thermal stability, their methanolysis to methyl 2-(4-hydroxyphenoxy)benzoates, and their reductive cleavage to 2,4'-dihydrobenzophenones.Treatment of the benzophenones with base gave xanthones.An attempt to synthesize dehydrogriseofulvin (1) by this method failed.
