46035-71-6

Basic information

• Product Name: 2-(2-METHOXY-5-METHYLPHENYL)ETHANAMINE
• Synonyms: Benzeneethanamine, 2-methoxy-5-methyl-;2-(2-methoxy-5-methylphenyl)ethan-1-amine
• CAS NO: 46035-71-6
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Mol File: 46035-71-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 255.9°Cat760mmHg
• Flash Point: 105.6°C
• Appearance: /
• Density: 0.994g/cm³
• Vapor Pressure: 0.0159mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 2-(2-METHOXY-5-METHYLPHENYL)ETHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHOXY-5-METHYLPHENYL)ETHANAMINE(46035-71-6)
• EPA Substance Registry System: 2-(2-METHOXY-5-METHYLPHENYL)ETHANAMINE(46035-71-6)

Safety Data

• Hazardous Substances Data: 46035-71-6(Hazardous Substances Data)

Usage

Chemical Class

2-(2-Methoxy-5-methylphenyl)ethanamine belongs to the class of organic compounds known as phenylpropylamines.

Common Uses

The compound is commonly used as a stimulant and decongestant.

Mechanism of Action

2-(2-Methoxy-5-methylphenyl)ethanamine acts as a sympathomimetic agent, meaning it mimics the effects of the sympathetic nervous system.

Physiological Effects

As a sympathomimetic agent, 2-(2-Methoxy-5-methylphenyl)ethanamine leads to increased heart rate, blood pressure, and dilation of bronchial passages.

Use in Supplements

The compound has been used in various formulations of dietary supplements and sports performance supplements.

Banned Substance

2-(2-Methoxy-5-methylphenyl)ethanamine is considered a banned substance in many sports organizations due to its potential for abuse and stimulant effects.

InChI:InChI=1/C10H15NO/c1-8-3-4-10(12-2)9(7-8)5-6-11/h3-4,7H,5-6,11H2,1-2H3

Upstream product

• 7048-42-2 (2-methoxy-5-methylphenyl)-acetonitrile 
• 7048-41-1 2-methoxy-5-methylbenzyl chloride 
• 7048-40-0 (2-methoxy-5-methylphenyl)methanol 
• 63113-79-1 methyl 2-methoxy-5-methylbenzoate 

Relevant articles and documents

Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-Iodomelatonin Binding Sites

New melatonin-like agents were designed from the frameworks of 2,5-dimethoxyphenethylamine, an important structural moiety for the 5-HT receptor, and (2-methoxynaphthyl)ethylamine.The compounds were synthesized by classical methods and evaluated in binding assays with chicken brain membranes using 2-(125I>iodomelatonin as the radioligand.Preliminary studies on the series of N-acyl-disubstituted phenethylamines showed the favorable role of the methoxy group in the ortho position of the side chain on the affinity for the receptor ( Ki = 8 +/- 0.2 nM ) for N-propionamide (3o).This effect was confirmed in a series of the naphthalene derivatives, a bioisosteric moiety of the indole ring, and several potent ligands for melatonin binding sites were prepared such as N-propionamide (4b) ( Ki = 0.67 +/- 0.05 nM ) and N-cyclopropylformamide (Ki = 0.05 +/- 0.004 nM ( (4k).Structure-activity relationships are discussed with regard to melatonin and bioisosteric naphthalenic compound 2.The Ki value for 4b was affected to a similar extent to that of melatonin by GTP-γ-S or Mn2+ in competition experiments, suggesting an agonist profile for this compound.