7048-40-0 Usage
Description
(2-Methoxy-5-methylphenyl)methanol, also known as guaiacol, is a colorless to pale yellow liquid chemical compound with a faint aromatic odor. It is commonly used as a flavoring agent in the food industry and as a precursor for the synthesis of pharmaceuticals and fragrances. Guaiacol also has a variety of industrial applications, including its use as a reagent in organic synthesis and as a raw material for the production of antioxidant additives.
Uses
Used in Food Industry:
(2-Methoxy-5-methylphenyl)methanol is used as a flavoring agent for its aromatic properties, enhancing the taste and aroma of various food products.
Used in Pharmaceutical Industry:
(2-Methoxy-5-methylphenyl)methanol is used as a precursor for the synthesis of pharmaceuticals, contributing to the development of new medications.
Used in Fragrance Industry:
(2-Methoxy-5-methylphenyl)methanol is used as a precursor for the synthesis of fragrances, providing unique scents for various products.
Used in Organic Synthesis:
(2-Methoxy-5-methylphenyl)methanol is used as a reagent in organic synthesis, aiding in the production of various chemical compounds.
Used in Antioxidant Additives Production:
(2-Methoxy-5-methylphenyl)methanol is used as a raw material for the production of antioxidant additives, which help prevent the oxidation and degradation of materials in various industries.
Safety Precautions:
It is important to handle (2-Methoxy-5-methylphenyl)methanol with care, as it can cause irritation to the eyes, skin, and respiratory system, and may be harmful if ingested or inhaled in large quantities.
Check Digit Verification of cas no
The CAS Registry Mumber 7048-40-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,4 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7048-40:
(6*7)+(5*0)+(4*4)+(3*8)+(2*4)+(1*0)=90
90 % 10 = 0
So 7048-40-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H13Cl2FO3/c23-15-4-3-14(19(24)10-15)9-21-22(26)18-8-7-17(11-20(18)28-21)27-12-13-1-5-16(25)6-2-13/h1-11H,12H2
7048-40-0Relevant articles and documents
Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite
Kaga, Atsushi,Hayashi, Hirohito,Hakamata, Hiroyuki,Oi, Miku,Uchiyama, Masanobu,Takita, Ryo,Chiba, Shunsuke
supporting information, p. 11807 - 11811 (2017/09/20)
A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.
Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-Iodomelatonin Binding Sites
Langlois, Michel,Bremont, Beatrice,Shen, Shuren,Poncet, Annie,Andrieux, Jean,et al.
, p. 2050 - 2060 (2007/10/02)
New melatonin-like agents were designed from the frameworks of 2,5-dimethoxyphenethylamine, an important structural moiety for the 5-HT receptor, and (2-methoxynaphthyl)ethylamine.The compounds were synthesized by classical methods and evaluated in binding assays with chicken brain membranes using 2-(125I>iodomelatonin as the radioligand.Preliminary studies on the series of N-acyl-disubstituted phenethylamines showed the favorable role of the methoxy group in the ortho position of the side chain on the affinity for the receptor ( Ki = 8 +/- 0.2 nM ) for N-propionamide (3o).This effect was confirmed in a series of the naphthalene derivatives, a bioisosteric moiety of the indole ring, and several potent ligands for melatonin binding sites were prepared such as N-propionamide (4b) ( Ki = 0.67 +/- 0.05 nM ) and N-cyclopropylformamide (Ki = 0.05 +/- 0.004 nM ( (4k).Structure-activity relationships are discussed with regard to melatonin and bioisosteric naphthalenic compound 2.The Ki value for 4b was affected to a similar extent to that of melatonin by GTP-γ-S or Mn2+ in competition experiments, suggesting an agonist profile for this compound.
