7048-42-2

Usage

InChI:InChI=1/C10H11NO/c1-8-3-4-10(12-2)9(7-8)5-6-11/h3-4,7H,5H2,1-2H3

Upstream product

• 22002-45-5 2-bromo-4-methylanisole 
• 75-05-8 acetonitrile 
• 773837-37-9 sodium cyanide 
• 7048-41-1 2-methoxy-5-methylbenzyl chloride 
• 63113-79-1 methyl 2-methoxy-5-methylbenzoate 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 7048-40-0 (2-methoxy-5-methylphenyl)methanol 

Downstream Products

• 110355-17-4 1,3-bis(2-methoxy-5-methylphenyl)-2-propanone 
• 58506-25-5 ethyl 2-methoxy-5-methylbenzeneacetate 
• 46035-71-6 2-(2-methoxy-5-methylphenyl)ethylamine 
• 58506-24-4 2-methoxy-5-methylbenzeneacetic acid 

Relevant academic research and scientific papers

SMALL MOLECULE CORRECTORS OF MAMMALIAN SLC6A8 FUNCTION

Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with mutation in a protein.

3,9-DIAZASPIRO[5.5]UNDECANE COMPOUNDS

The present invention covers 3,9-diazaspiro[5.5]undecane compounds of general formula (I) and general formula (I-a), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

8-OXOADENINE COMPOUND

An 8-oxoadenine compound useful as an immuno-modulator having specific activity against Th1/Th2, specifically a prophylactic and therapeutic agent for a topical application for allergic diseases, viral siseases and cancers, which is represented by the following formula (1): , wherein A is a group of a formula represented by the formula (2): , wherein R2 is a substituted or unsubstituted alkyl group and so on, R3 is hydrogen atom or an alkyl group, R is a halogen atom and so on, n is 0-2, X1 is oxygen atom, Z is straight or branched chain alkylene, and R1 is an alkyl group which is optionally substituted by hydroxy group, an alkoxy group, alkoxycarbonyl group and so on, or its pharmaceutically acceptable salt.

Design and Synthesis of New Naphthalenic Derivatives as Ligands for 2-Iodomelatonin Binding Sites

New melatonin-like agents were designed from the frameworks of 2,5-dimethoxyphenethylamine, an important structural moiety for the 5-HT receptor, and (2-methoxynaphthyl)ethylamine.The compounds were synthesized by classical methods and evaluated in binding assays with chicken brain membranes using 2-(125I>iodomelatonin as the radioligand.Preliminary studies on the series of N-acyl-disubstituted phenethylamines showed the favorable role of the methoxy group in the ortho position of the side chain on the affinity for the receptor ( Ki = 8 +/- 0.2 nM ) for N-propionamide (3o).This effect was confirmed in a series of the naphthalene derivatives, a bioisosteric moiety of the indole ring, and several potent ligands for melatonin binding sites were prepared such as N-propionamide (4b) ( Ki = 0.67 +/- 0.05 nM ) and N-cyclopropylformamide (Ki = 0.05 +/- 0.004 nM ( (4k).Structure-activity relationships are discussed with regard to melatonin and bioisosteric naphthalenic compound 2.The Ki value for 4b was affected to a similar extent to that of melatonin by GTP-γ-S or Mn2+ in competition experiments, suggesting an agonist profile for this compound.

Preorganized Macrocyclic Ligands: A Novel Approach to Functionalized Hemispherands via Aromatization

Reaction of the 1,3-diaryl-2-propanone moiety in the flexible 18-membered macrocycle 2b with nitromalonodialdehyde to yield the hemispherand 1f represents a novel method for the synthesis of partly preorganized macrocyclic ligands.The O-O repulsion in mac