460747-42-6

Basic information

• Product Name: Methanone, (2-fluorophenyl)(4-hydroxy-3-iodophenyl)-
• CAS NO: 460747-42-6
• Molecular Formula: C13H8FIO2
• Molecular Weight: 342.108
• Mol File: 460747-42-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, (2-fluorophenyl)(4-hydroxy-3-iodophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-fluorophenyl)(4-hydroxy-3-iodophenyl)-(460747-42-6)
• EPA Substance Registry System: Methanone, (2-fluorophenyl)(4-hydroxy-3-iodophenyl)-(460747-42-6)

Safety Data

• Hazardous Substances Data: 460747-42-6(Hazardous Substances Data)

Upstream product

• 101969-75-9 (2-fluorophenyl)(4-hydroxyphenyl)methanone 
• 66938-29-2 (2-fluorophenyl)(4-methoxyphenyl)methanone 

Relevant articles and documents

Synthesis and biological evaluation of XB-1 analogues as novel histamine H3 receptor antagonists and neuroprotective agents

A novel class of H3 receptor antagonists, XB-1 analogues based on benzophenone or oxydibenzene scaffolds were synthesized, and their biological activities were evaluated to determine their in vitro neuroprotective effects against Aβ25-35-induced damage in primary cortical neurons and against glutamate-induced neuronal injury in primary cerebellar granule neurons. The results indicated that all of the tested analogues displayed neuroprotective activity at 0.1 μM or 1 μM. These findings may provide new insights into the development of novel promising H3 receptor antagonists with potential neuroprotective activity.

Novel amines as histamine-3 receptor ligands and their therapeutic applications

Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.