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Usage

Uses

Used in Inks and Coatings Industry:
2-Fluoro-4'-hydroxybenzophenone is used as a photoinitiator and UV absorber for protecting inks and coatings from the damaging effects of ultraviolet light. Its inclusion in these materials helps to prevent fading, discoloration, and degradation, thereby enhancing their durability and longevity.
Used in Adhesives Industry:
In the adhesives industry, 2-Fluoro-4'-hydroxybenzophenone serves as a UV stabilizer, ensuring that adhesives maintain their bonding strength and integrity when exposed to sunlight or other UV sources. This is crucial for applications where the adhesive is exposed to outdoor conditions or UV-rich environments.
Used in Plastics Industry:
2-Fluoro-4'-hydroxybenzophenone is utilized in the plastics industry as a UV stabilizer to protect plastic materials from UV-induced degradation, which can cause embrittlement, yellowing, and loss of mechanical properties. Its use ensures that plastics remain functional and aesthetically pleasing over time.
Used in Pharmaceutical Synthesis:
2-Fluoro-4'-hydroxybenzophenone is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical properties make it a valuable building block for creating new and effective medications.
Used in Environmental Research:
2-Fluoro-4'-hydroxybenzophenone has been studied for its potential environmental impact and toxicity, particularly in aquatic ecosystems. Understanding its behavior in the environment is crucial for assessing its safety and managing its use responsibly in industrial applications.

Upstream product

• 766-49-4 (2-fluorophenyl)acetylene 
• 106-51-4 p-benzoquinone 
• 393-52-2 2-Fluorobenzoyl chloride 
• 100-66-3 methoxybenzene 
• 66938-29-2 (2-fluorophenyl)(4-methoxyphenyl)methanone 

Downstream Products

• 1415919-87-7 methyl (2E)-2-(2-((4-(2-fluorobenzoyl)phenoxy)methyl)phenyl)3-(methoxy)acrylate 
• 1421854-27-4 1-(1-(4-(benzyloxy)phenyl)vinyl)-2-fluorobenzene 
• 1421854-28-5 2-(4-(benzyloxy)phenyl)-2-(2-fluorophenyl)ethanol 
• 1421854-29-6 2-(4-(benzyloxy)phenyl)-2-(2-fluorophenyl)acetaldehyde 
• 1421854-30-9 4-(4-(benzyloxy)phenyl)-4-(2-fluorophenyl)cyclohex-2-enone 
• 1421854-31-0 4-(2-fluorophenyl)-4-(4-hydroxyphenyl)cyclohexanone 
• 1421854-32-1 4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone 
• 1421854-16-1 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol 
• 1421854-33-2 4-(2-fluorophenyl)-4-(4-methoxyphenyl)cyclohexanone 
• 1421854-17-2 1-(4,4-difluoro-1-(4-methoxyphenyl)cyclohexyl)-2-fluorobenzene 
• 1147713-98-1 (4-(benzyloxy)phenyl)(2-fluorophenyl)methanone 
• 1421854-18-3 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol 
• 1446099-54-2 (4-(2-chloroethoxy)phenyl)(2-fluorophenyl)methanone 

Relevant academic research and scientific papers

Visible Light-Mediated [2 + 2] Cycloaddition Reactions of 1,4-Quinones and Terminal Alkynes

A single-step synthesis of 4-hydroxy-functionalized bi-aryl and aryl/alkyl ketones via oxidative coupling of terminal alkynes with benzoquinones is reported. Furthermore, with naphthoquinones, owing to the cross-resonance of carbonyl with the aromatic ring, alkene-alkyne cycloaddition is more favored to give four-membered carbocyclic adducts, thereby precluding the requirement of preactivated alkynes.

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

We synthesized and evaluated a series of compounds for their allosteric modulation at the Kv11.1 (hERG) channel. Most compounds were negative allosteric modulators of [3H]dofetilide binding to the channel, in particular 7f, 7h-j and 7p. Compounds 7f and 7p were the most potent negative allosteric modulators amongst all ligands, significantly increasing the dissociation rate of dofetilide in the radioligand kinetic binding assay, while remarkably reducing the affinities of dofetilide and astemizole in a competitive displacement assay. Additionally, both 7f and 7p displayed peculiar displacement characteristics with Hill coefficients significantly distinct from unity as shown by e.g., dofetilide, further indicative of their allosteric effects on dofetilide binding. Our findings in this investigation yielded several promising negative allosteric modulators for future functional and clinical research with respect to their antiarrhythmic propensities, either alone or in combination with known Kv11.1 blockers.

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention

H3 receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H 3 receptors, with Ki values of 0.1-5.8 nM. Analogues were discovered with potent (0.01-1 mg/kg) cognition and attention enhancing properties in animal models. One compound in particular, 4-(2-[2-(2(R)- methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile (ABT-239), combined potent and selective H3 receptor antagonism and excellent pharmacokinetic and metabolic properties across species, with full efficacy in two behavioral models: a five-trial inhibitory avoidance acquisition model in rat pups at 0.1 mg/kg and a social recognition memory model in adult rats at 0.01 mg/kg. Furthermore, this compound did not stimulate locomotor activity and showed high selectivity for the induction of behavioral efficacy versus central nervous system based side effects. The potency and selectivity of this compound and of analogues from this class support the potential of H3 receptor antagonists for the treatment of cognitive dysfunction.