461-92-7

Usage

Uses

Used in Organic Synthesis:
1,1,1-Trifluoro-6-methylheptane-2,4-dione is utilized as a building block in organic synthesis for the creation of more complex molecules. Its distinctive structure and the trifluoromethyl group's influence on stability and reactivity make it a beneficial component in the synthesis of advanced chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1,1,1-trifluoro-6-methylheptane-2,4-dione serves as a key intermediate in the development of new drugs. Its unique properties allow for the exploration of its potential in medicinal chemistry, where it can be incorporated into drug candidates to enhance their efficacy, selectivity, or other pharmacological properties.
Used in the Development of New Materials:
1,1,1-TRIFLUORO-6-METHYLHEPTANE-2,4-DIONE's properties also make it suitable for the development of new materials with specific characteristics. The trifluoromethyl group can impart particular chemical and physical properties to materials, which can be advantageous in various applications, such as in coatings, polymers, or other industrial materials.

InChI:InChI=1/C8H11F3O2/c1-5(2)3-6(12)4-7(13)8(9,10)11/h5H,3-4H2,1-2H3

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 108-10-1 4-methyl-2-pentanone 
• 431-47-0 trifluoroacetic acid-methyl ester 

Downstream Products

• 1187180-09-1 1,1,1-trifluoro-5-methyl-4-(3,4-difluorophenylamino)hept-3-en-2-one 

Relevant academic research and scientific papers

Synthesis and characterization of some 3-acyl-4-amino-1-aryl-1H-pyrazoles

(Chemical Equation Presented) A series of 3-acyl-4-amino-1-aryl-1H- pyrazoles has been prepared by reaction of β-enaminones with benzenediazonium tetrafluoroborates substituted especially by fluorine-containing groups (F, CF3, and OCF3/su

Keto-enol and enol-enol tautomerism in trifluoromethyl-β-diketones

The keto-enol (K?E) and enol-enol (E?E) equilibria of a variety of trifluoromethyl-β-diketones were investigated using 1H, 13C, 19F NMR spectroscopy, infrared spectroscopy and ultraviolet-visible spectrophotometry in nonpolar solvents. In general, NMR, IR and UV spectral evidence indicates that trifluoromethyl-β-diketones exist as mixtures of two chelated cis-enol forms in nonpolar media. Infrared spectroscopy and ultraviolet spectrophotometry show the E?E equilibrium lies in the direction of the enol form which maximizes conjugation in most cases. Exceptions are noted and discussed.

Synthesis of fluorinated heterocycles

Selected 1,3-diketones having a trifluoromethyl group and/or a fluorine in the 2-position were condensed with aromatic hydrazines, hydroxylamine, urea, thiourea, guanidine, and substituted anilines producing pyrazoles, isoxazoles, pyrimidines, and quinolines, respectively, in yields ranging from 27 to 87%.

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3

The identification of indeno[1,2-c]pyrazol-4-ones as inhibitors of cyclin-dependent kinases (CDKs) has led to the discovery of a series of novel and potent compounds. Herein, we report the effects of substitutions at C3 of the indeno[1,2-c]pyrazol-4-one core with alkyls, heterocycles, and substituted phenyls. Substitutions at the para position of the phenyl ring at C3 were generally well-tolerated; however, larger groups were generally inactive. For alkyls directly attached to C3, longer chain substituents were not tolerated; however, shorter alkyl groups and cyclic alkyls were acceptable. In general, the heterocycles at C3 gave the most potent analogues. One such heterocycle, 24j, was examined in detail and was determined to have a biological profile consistent with CDK inhibition. An X-ray crystal structure of one of the alkyl compounds, 13q, complexed with CDK2 was determined and showed the inhibitor residing in the adenosine 5′-triphosphate pocket of the enzyme.