461051-91-2

Upstream product

• 123621-29-4 Triethyl-(4-methoxy-benzyl)-silane 
• 824-94-2 p-methoxybenzyl chloride 
• 994-30-9 triethylsilyl chloride 
• 24588-72-5 2-(4-methoxyphenyl)-1,3-dithiane 
• 461051-85-4 2-(4-methoxyphenyl)-2-triethylsilyl-1,3-dithiane 

Downstream Products

• 4842-39-1 R-(-)-1-(4-methoxyphenyl)-2-hydroxy-2-phenylethanone 
• 1185262-63-8 1-(4-methoxyphenyl)-2-phenyl-2-(triethylsilyloxy)propan-1-one 
• 1300718-87-9 (R(S))-N-[(1R,2S)-1,2-bis(4-methoxyphenyl)-2-(triethylsilyloxy)cyclopropyl]-2-methylpropane-2-sulfinamide 
• 1300718-79-9 (R(S))-N-[(1R,2S)-1-phenyl-2-(4-methoxyphenyl)-2-(triethylsilyloxy)cyclopropyl]-2-methylpropane-2-sulfinamide 
• 1304789-97-6 C₂₂H₃₀O₃Si 
• 1273386-93-8 C₂₅H₃₈O₃Si₂ 
• 1273386-94-9 C₂₅H₃₈O₃Si₂ 
• 1273386-92-7 C₂₂H₄₀O₃Si₂ 
• 1273386-91-6 C₂₇H₅₀O₃Si₂ 
• 1273386-86-9 C₁₉H₃₄O₃Si₂ 
• 881883-35-8 (R)-4-(4-methoxyphenyl)-N,N-dimethyl-4-oxo-3-phenylbutyramide 

Relevant academic research and scientific papers

Enantioselective Synthesis of Chiral 3-Substituted-3-silylpropionic Esters via Rhodium/Bisphosphine-Thiourea-Catalyzed Asymmetric Hydrogenation

We have successfully developed the asymmetric hydrogenation of β-silyl-α,β-unsaturated esters to prepare chiral 3-substituted-3-silylpropionic ester products catalyzed by rhodium/bisphosphine-thiourea (ZhaoPhos) with excellent results (up to 97% yield, >99% ee, 1500 TON). Moreover, our hydrogenation products can be efficiently converted to other important organic molecules, such as chiral ethyl (R)-3-hydroxy-3-phenylpropanoate or (R)-3-[dimethyl(phenyl)silyl]-3-phenylpropanoic acid. (Figure presented.).

Tandem carbon-carbon bond constructions via catalyzed cyanation/Brook rearrangement/C-acylation reactions of acylsilanes

(equation presented) A tandem nucleophile-catalyzed cyanation/Brook rearrangement/C-acylation has been developed. Phase transfer cocatalysts facilitate cyanide-catalyzed reactions between acylsilanes and cyanoformates to afford protected tertiary carbinol