4842-39-1

Upstream product

• 22711-21-3 4-methoxybenzil 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 100-52-7 benzaldehyde 
• 461051-91-2 4-methoxyphenyl triethylsilyl ketone 
• 4254-17-5 4-methoxybenzoin 
• 123-11-5 4-methoxy-benzaldehyde 
• 611-71-2 (R)-Mandelic Acid 
• 288374-65-2 (R)-(-)-N-methyl-N-methoxy(2-hydroxy-2-phenyl)acetamide 

Downstream Products

• 1889-84-5 4'-methoxybenzoin 

Relevant academic research and scientific papers

Pd-Catalyzed Decarboxylative Cycloaddition for the Synthesis of Highly Substituted δ-Lactones and Lactams

An efficient palladium-catalyzed decarboxylative cycloaddition process of vinyl cyclic carbonates and vinyloxazolidinones for the synthesis of highly substituted δ-lactone and δ-lactam derivatives was developed. This protocol exhibits several unique characteristics, including broad substrate scope, good functional group tolerance, and operational convenience, which enables a regioselective access to a variety of lactone and lactam scaffolds in moderate to good yield. The redox-neutral catalytic system promotes formation of substituted scaffolds with in situ generation of a cyclic tetra-substituted double bond functionality.

Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates

Chiral oxidovanadium(V) methoxides prepared from 3,5-disubstituted-N- salicylidene-l-tert-butylglycines and vanadyl sulfate in air-saturated MeOH serve as highly enantioselective catalysts for asymmetric aerobic oxidations and kinetic resolution of alkyl, aryl, and heteroaryl α-hydroxy-ketones with differed α-substituents at ambient temperature in toluene or TBME (tert-butyl methyl ether). The best scenarios involve the use of complexes which bear the tridendate templates derived from 3,5-diphenyl- or 3-o-biphenyl-5-nitro-salicyaldehyde. The kinetic resolution selectivities of the aerobic oxidation process are in the range of 12 to >1000 based on the selectivity factors (krel).

Metallophosphites as Umpolung Catalysts: The Enantioselective Cross Silyl Benzoin Reaction

Carbonyl polarity reversal (umpolung) has been realized employing metallophosphites as catalysts. As a result, nonenzymatic asymmetric cross silyl benzoin reactions have been achieved, giving optically active silyl ether-protected benzoin adducts. The reaction is general with respect to aryl, alkyl, and heterocyclic substrates with good to excellent yields and good to excellent enantioselectivities. Copyright

Microbial Reduction of 1,2-Diketones to Optically Active α-Hydroxyketones

The microorganisms that reduce benzil to optically active benzoin were screened.Xanthomonas oryzae IAM 1657 was selected as the best strain, which resulted in the formation of (R)-(-)-benzoin.This biochemical reduction was applied to other 1,2- and 1,3-diketones to find that only 1,2-diarylethanediones were reduced smoothly to afford the corresponding ketols.