46113-76-2Relevant academic research and scientific papers
A Novel and Practical Continuous Flow Chemical Synthesis of Cannabidiol (CBD) and its CBDV and CBDB Analogues
Chiurchiù, Elena,Sampaolesi, Susanna,Allegrini, Pietro,Ciceri, Daniele,Ballini, Roberto,Palmieri, Alessandro
supporting information, p. 1286 - 1289 (2021/02/05)
Cannabidiol is one of the main non-psychoactive cannabinoids present in Cannabis sativa and, in the last decade, it is gaining great interest among the scientific community for its pharmaceutical, nutraceutical, and cosmetic applications. Herein, we report the first continuous flow chemical synthesis of cannabidiol (CBD) and its analogues cannabidivarin (CBDV) and cannabidibutol (CBDB). This approach permits to synthesize products in very good yields (55–59 %), limiting the formation of psychoactive and illegal cannabinoids such as tetrahydrocannabinol (THC).
Cannabidiol derivative as well as preparation method and medical application thereof
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, (2021/07/10)
The invention relates to a cannabidiol derivative and application thereof in medicine, in particular to a pyrimidine derivative as shown in a general formula (I), or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a co-crystal thereof, and definition of each substituent in the general formula (I) is the same as that in the specification.
Preparation of 2,2-dimethylchroman-4-ones from 5-alkyl-substituted resorcinols: Microwave-assisted synthesis and theoretical calculations
Morales, Paula,Azofra, Luis Miguel,Cumella, Jose,Hernandez-Folgado, Laura,Roldan, Maria,Alkorta, Ibon,Jagerovic, Nadine
, p. 319 - 332 (2014/03/21)
The influence of different 5-alkyl-substituted resorcinols on the formation of 2,2-dimethylchroman- 4-ones is examined experimentally and theoretically. Structures are fully assigned by means of experimental and theoretical 13C and 1H NMR chemical shifts.
PHENYL-UREA AND PHENYL-CARBAMATE DERIVATIVES AS INHIBITORS OF PROTEIN AGGREGATION
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Page/Page column 0089, (2013/10/21)
The present invention relates to certain phenyl-urea and phenyl-carbamate derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, and multiple system atrophy.
Biosynthesis of primin and miconidin and its derivatives
Horper, Wolfgang,Marner, Franz-Josef
, p. 451 - 456 (2007/10/03)
Numerous 2-methoxy-6-n-alkyl-1,4-benzoquinones with interesting biological activities have been found as constituents of plants and plant seeds. The most prominent is primin, the n-pentyl derivative, which is stored in trichomes on leaves and stems of Primula obconica and is responsible for primrose dermatitis. The biosynthesis of primin was studied by feeding experiments with radioactively labelled precursors and unlabelled homologues. Copyright
BIOLOGICALLY ACTIVE PHENOLIC METABOLITES OF A VERTICICLADIELLA SPECIES
Ayer, William A.,Browne, Lois M.,Lovell, Sarah H.
, p. 2267 - 2272 (2007/10/02)
The metabolites produced when a Verticicladiella species (Canadian Forestry Service strain C728), the causative agent of the black stain root disease of many conifers, is grown in liquid culture have been investigated.Orcinol, orcinol monomethyl ether, 1,3,6,8-tetrahydroxyanthraquinone, and the α-L-rhamnopyranosides of orcinol and orcinol methyl ether have been isolated and indentified.Orcinol methyl ether and its rhamnoside both show antibacterial activity and orcinol methyl ether also inhibits the growth of pine germlings.The general antibacterial activity of 5-alkylresorcinols and their monomethyl ethers is reported.-Key Word Index-Verticicladiella sp.; Deuteromycontina; blue-stain fungus; phytotoxin; phenols; methylorcinol rhamnoside; phenol monomethyl ethers; antiseptics.
