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461451-35-4

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461451-35-4 Usage

General Description

2-IMIDAZO[1,2-A]PYRIMIDIN-7-YL-PROPAN-2-OL is a chemical compound that consists of a imidazopyrimidinyl ring fused to a propanol group. It is a synthetic compound that may have potential pharmacological properties due to its structural features. The compound's specific chemical properties and potential applications would need to be further investigated through research and experimentation.

Check Digit Verification of cas no

The CAS Registry Mumber 461451-35-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,1,4,5 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 461451-35:
(8*4)+(7*6)+(6*1)+(5*4)+(4*5)+(3*1)+(2*3)+(1*5)=134
134 % 10 = 4
So 461451-35-4 is a valid CAS Registry Number.

461451-35-4Relevant articles and documents

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders

Goodacre, Simon C.,Street, Leslie J.,Hallett, David J.,Crawforth, James M.,Kelly, Sarah,Owens, Andrew P.,Blackaby, Wesley P.,Lewis, Richard T.,Stanley, Joanna,Smith, Alison J.,Ferris, Pushpinder,Sohal, Bindi,Cook, Susan M.,Pike, Andrew,Brown, Nicola,Wafford, Keith A.,Marshall, George,Castro, José L.,Atack, John R.

, p. 35 - 38 (2007/10/03)

A series of high-affinity GABAA agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA Aα2 and -α3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g and the 7-propan-2-olimidazopyrimidine 14k are anxiolytic in both conditioned and unconditioned animal models of anxiety with minimal sedation observed at full BZ binding site occupancy.

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