607716-58-5

Basic information

• Product Name: 2-[3-(3-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol
• Synonyms: 2-[3-(3-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol
• CAS NO: 607716-58-5
• Molecular Weight: 305.739
• Mol File: 607716-58-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-(3-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(3-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol(607716-58-5)
• EPA Substance Registry System: 2-[3-(3-chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol(607716-58-5)

Safety Data

• Hazardous Substances Data: 607716-58-5(Hazardous Substances Data)

Upstream product

• 10235-71-9 3-Acetoxy-3-methyl-2-butanon 
• 115-22-0 3-Hydroxy-3-methyl-2-butanone 
• 463335-45-7 acetic acid 4,4-diethoxy-1,1-dimethyl-2-oxo-butyl ester 
• 461451-35-4 2-(imidazo[1,2-a]pyrimidin-7-yl)propan-2-ol 
• 60811-21-4 1-bromo-3-chloro-4-fluorobenzene 

Relevant articles and documents

Efficient synthesis of a GABAA α2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach

A practical synthesis of 2-[3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo[1,2- a]pyrimidin-7-yl]-propan-2-ol (1), an oral GABAA α 2/3-selective agonist, is described. The five-step process, which afforded 1 in 40% overall yield, included imidazopyrimidine 2 and pyridine boronic acid 4 as key fragments. The synthesis is highlighted by consecutive Pd-catalyzed coupling steps to assemble the final free base 1 in high yield and regioselectivity. A novel method for Pd removal in the final step is also described.