46155-89-9

Basic information

• Product Name: 1,3-DiMethyl-1H-pyrrolo[3,2-d]pyriMidine-2,4(3H,5H)-dione
• Synonyms: 1,3-DiMethyl-1H-pyrrolo[3,2-d]pyriMidine-2,4(3H,5H)-dione
• CAS NO: 46155-89-9
• Molecular Formula: C₈H₉N₃O₂
• Molecular Weight: 179.17596
• Mol File: 46155-89-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 369.6°C at 760 mmHg
• Flash Point: 177.3°C
• Appearance: /
• Density: 1.381g/cm³
• Vapor Pressure: 1.17E-05mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,3-DiMethyl-1H-pyrrolo[3,2-d]pyriMidine-2,4(3H,5H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DiMethyl-1H-pyrrolo[3,2-d]pyriMidine-2,4(3H,5H)-dione(46155-89-9)
• EPA Substance Registry System: 1,3-DiMethyl-1H-pyrrolo[3,2-d]pyriMidine-2,4(3H,5H)-dione(46155-89-9)

Safety Data

• Hazardous Substances Data: 46155-89-9(Hazardous Substances Data)

Usage

General Description

1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione is a chemical compound with the molecular formula C8H8N2O2. It belongs to the class of pyrrolopyrimidine compounds and is a heterocyclic compound containing nitrogen atoms in the ring structure. This chemical is commonly used in the pharmaceutical industry as a building block in the synthesis of various pharmaceutical drugs and biologically active compounds. It is known for its potential pharmacological properties and is being studied for its possible applications in drug development. Additionally, this compound has been reported to have anti-cancer and anti-inflammatory activities, making it a subject of research in the field of medicinal chemistry. Overall, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione is an important and versatile chemical in the pharmaceutical and biomedical fields.

InChI:InChI=1/C8H9N3O2/c1-10-5-3-4-9-6(5)7(12)11(2)8(10)13/h3-4,9H,1-2H3

Upstream product

• 303768-04-9 C₁₂H₁₆N₄O₅ 
• 13509-52-9 1,3,6-trimethyluracil 
• 19674-60-3 3,6-dimethyluracil 
• 55326-07-3 1,3,6-trimethyl-5-nitrouracil 
• 116705-30-7 1,3-dimethyl-6-(2-dimethylaminovinyl)-5-nitrouracil 
• 55276-27-2 1,3-dimethyl-6-<2-(dimethylamino)vinyl>-5-nitrouracil 
• 61541-41-1 6-azido-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 1560-54-9 allyltriphenylphosphonium bromide 

Downstream Products

• 55276-30-7 1,3,5-trimethylpyrrolo[3,2-d]pyrimidine-2,4(1H,3H)-dione 
• 1366000-20-5 N-(2,4-difluoro-phenyl)-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-acetamide 
• 1366000-19-2 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(3-iodo-phenyl)-acetamide 
• 1366000-43-2 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-[4-(4-hexyl-phenyl)-thiazol-2-yl]-acetamide 
• 1366000-18-1 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d ]pyrimidin-5-yl)-N-(4-iodo-phenyl)-acetamide 
• 1366000-17-0 N-(4-chloro-phenyl)-2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-acetamide 
• 1366000-16-9 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d ]pyrimidin-5-yl)-N-(4-fluoro-phenyl)-N-methyl-acetamide 
• 1366000-15-8 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(4-fluoro-phenyl)-acetamide 
• 1366000-14-7 (1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-acetic acid 
• 1246275-16-0 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d ]pyrimidin-5-yl)-N-[4-(4-fluoro-3-trifluoromethyl-phenyl)-thiazol-2-yl]-acetamide 
• 1366000-42-1 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d ]pyrimidin-5-yl)-N-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-acetamide 
• 1366000-41-0 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-[4-(4-iodo-phenyl)-thiazol-2-yl]-acetamide 
• 1366000-40-9 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-[4-(4-fluoro-phenyl)-thiazol-2-yl]-acetamide 
• 1366000-39-6 2-(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrrolo[3,2-d]pyrimidin-5-yl)-N-(4-phenyl-thiazol-2-yl)-acetamide 

Relevant articles and documents

Pyrrolopyrimidines. 1. Electrophilic Substitution Reactions of 1,3-Dimethylpyrrolopyrimidine-2,4-dione

The reactions of halogenation, aminomethylation, acylation, and azo coupling in 1,3-dimethylpyrrolopyrimidine-2,4-dione proceed at position 7, whereas nitration in acetic acid is direct primarily to position 6.In a number of cases, products of subs

FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl. Formula (I)

Pyrrolopyrimidines. 4. A convenient method for the production of 6-(2-aminovinyl)-5-nitropyrimidines and their transformation into pyrrolo[3,2-d]pyrimidines

A convenient method is proposed for the production of 6-(2- aminovinyl)pyrimidine-2,4-diones, involving the reaction of 6-methyluracils with triethyl orthoformiate and secondary amines.