55276-30-7

Upstream product

• 77-78-1 dimethyl sulfate 
• 46155-89-9 1,3-dimethylpyrrolo<3,2-d>pyrimidine-2,4-dione 
• 55276-27-2 1,3-dimethyl-6-<2-(dimethylamino)vinyl>-5-nitrouracil 
• 55326-07-3 1,3,6-trimethyl-5-nitrouracil 
• 13509-52-9 1,3,6-trimethyluracil 
• 19674-60-3 3,6-dimethyluracil 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Nitro derivatives of pyrrolo[3,2-d]pyrimidine-2,4-diones: Synthesis of amines and new polynuclear heterocycles based thereon

The nitration of 1,3-dimethylpyrrolo[3,2-d]pyrimidine-2,4-diones under different conditions led to the formation of their 6(7)-mono- and 6,7-dinitro derivatives which were reduced to the corresponding amines. The latter reacted with α- and β-dicarbonyl compounds, as well as with ortho-quinones to give a number of new polycyclic heteroaromatic systems.

Synthesis and structure-activity relationships of deazaxanthines: Analogs of potent A1- and A2-adenosine receptor antagonists

A set of 22 9-deazaxanthines (pyrrolo[3,2-d]pyrimidine-2,4-diones) and three 7-deazaxanthines (pyrrolo[2,3-d]pyrimidine-2,4-diones) with various substituents in the 1-, 3-, 7- or 9-, and 8-positions was synthesized and investigated in A1 and A2a adenosine receptor binding assays at rat brain cortical membranes and rat brain striatal membranes, respectively. 9- Deazaxanthines showed structure-activity relationships that were similar to those of xanthines. They were about equipotent to the corresponding xanthines at A2a adenosine receptors. 9-Deazaxanthines were generally at least 1-3- fold more potent than xanthines at A1 receptors and therefore exhibited higher A1 selectivities compared to the xanthines. 1,3-Dimethyl-8-(2- naphthyl)-9-deazaxanthine (19e) showed high affinity (K(i) = 26 nM) and selectivity for A1 adenosine receptors. A hydroxyl function at N7 of 9- deazaxanthines was unfavorable for A1 and A2a receptor binding. 7- Deazaxanthines were considerably less potent compared to xanthines and to 9- deazaxanthines at both receptor subtypes.

Application of Host-Guest Complexation Method to Isolation of Natural Product

Application of host-guest complexation method to isolation of caffeine, nicotine, and cholesterol fom tea and tabaco leaves, and gallstone, respectively, has been reported.Separations of strychnine and brucine, and sparteine and brucine by the same method were also reported.