46182-58-5

Basic information

• Product Name: C-(5-PHENYL-[1,3,4]OXADIAZOL-2-YL)-METHYLAMINE
• Synonyms: C-(5-PHENYL-[1,3,4]OXADIAZOL-2-YL)-METHYLAMINE;CHEMBRDG-BB 4100685;5-PHENYL-[1,3,4]OXADIAZOL-2-YL-METHYLAMINE;1-(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYLAMINE;3-Aminomethyl-5-phenyl-1,3,4-oxadiazole;(5-Phenyl-1,3,4-oxadiazol-2-yl)methanamine;1,3,4-Oxadiazole-2-methanamine, 5-phenyl-;1-(5-phenyl-1,3,4-oxadiazol-2-yl)methanamine(SALTDATA: oxalate 0.45H2O)
• CAS NO: 46182-58-5
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Mol File: 46182-58-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 325.5 °C at 760 mmHg
• Flash Point: 150.7 °C
• Appearance: /
• Density: 1.217 g/cm³
• Vapor Pressure: 0.000229mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• CAS DataBase Reference: C-(5-PHENYL-[1,3,4]OXADIAZOL-2-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(5-PHENYL-[1,3,4]OXADIAZOL-2-YL)-METHYLAMINE(46182-58-5)
• EPA Substance Registry System: C-(5-PHENYL-[1,3,4]OXADIAZOL-2-YL)-METHYLAMINE(46182-58-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 46182-58-5(Hazardous Substances Data)

Usage

General Description

C-(5-phenyl-[1,3,4]oxadiazol-2-yl)-methylamine is a chemical compound with the molecular formula C9H9N3O. It is a derivative of oxadiazole, a five-membered heterocyclic compound containing one oxygen and two nitrogen atoms. C-(5-PHENYL-[1,3,4]OXADIAZOL-2-YL)-METHYLAMINE is a potent inhibitor of enzymes and has been studied for its potential use in pharmaceuticals, particularly as an anti-cancer agent. Its unique structure and potential biological activity make it a subject of interest in medicinal chemistry and drug development.

InChI:InChI=1/C9H9N3O/c10-6-8-11-12-9(13-8)7-4-2-1-3-5-7/h1-5H,6,10H2

Upstream product

• 100-52-7 benzaldehyde 
• 934638-47-8 2-(azidomethyl)-5-phenyl-1,3,4-oxadiazole 
• 33575-83-6 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole 
• 613-94-5 benzoic acid hydrazide 
• 68496-63-9 5-phenyl-1,3,4-oxadiazole-2-carbonitrile 
• 1170-54-3 N'-benzoyl-2-benzyloxycarbonylamino-acetohydrazonic acid ethyl ester 

Downstream Products

• 1342816-74-3 2-cyanoethyl [(5-phenyl-1 ,3,4-oxadiazol-2-yl)methyl]dithiocarbamate 
• 486435-52-3 N-(5-phenyl-[1,3,4]oxadiazol-2-yl-methyl)-4-(4'-trifluoromethyl-biphenyl-2-carbonyl-amino)-1-methyl-pyrrole-2-carboxylic acid amide 

Relevant articles and documents

Design, synthesis and biological evaluation of nitrofuran-1,3,4-oxadiazole hybrids as new antitubercular agents

Three series of novel nitrofuran-1,3,4-oxadiazole hybrids were designed and synthesized as new anti-TB agents. The structure activity relationship study indicated that the linkers and the substituents on the oxadiazole moiety greatly influence the activity, and the substituted benzenes are more favoured than the cycloalkyl or heterocyclic groups. Besides, the optimal compound in series 2 was active against both MTB H37Rv strain and MDR-MTB 16883 clinical isolate and also displayed low cytotoxicity, low inhibition of hERG and good oral PK, indicating its promising potential to be a lead for further structural modifications.

INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS

The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.