4619-84-5Relevant academic research and scientific papers
CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF
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Paragraph 0344-0346, (2018/02/01)
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R1, R2, R3, Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.
Selective ortho-Methylthiomethylation of Phenols with Dimethyl Sulphoxide and Thionyl Chloride
Sato, Kikumasa,Inoue, Seiichi,Ozawa, Kimio,Tazaki, Michiko
, p. 2715 - 2719 (2007/10/02)
Thionyl chloride and phenyl chlorosulphinate have been shown to be useful activators for dimethyl sulphoxide in the selective preparation of ortho-methylthiomethylphenol via a sigmatropic rearrangement.By this process, ortho-methylthiomethylated phenols having a variety of 2- or 4-substituents (Me, Cl, OMe, NO2, and CO2Me) have been prepared in good yields.In contrast, similar reactions of 3-substituted phenols were affected by the electronic characters of the substituents.With more electron-donating groups such as OH and OMe in the 3-position, none of the expected products were obtained, but in the case of other 3-substituted phenols, two possible rearrangement products were obtained in moderate yields.
