155797-99-2 Usage
Uses
Used in Pharmaceutical Industry:
8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential applications in treating various medical conditions.
Used in Neuroimaging:
In the field of neuroimaging, 8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)- is used as a cocaine analog for the imaging of the dopamine transporter. Its ability to bind selectively to the dopamine transporter allows researchers to study the distribution and function of these transporters in the brain, which can provide valuable insights into the underlying mechanisms of various neurological and psychiatric disorders.
Used in Research and Development:
8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)is also used in research and development for the synthesis of novel compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science. Its unique structure and functional groups make it an attractive candidate for the development of new molecules with specific properties and functions.
Used in Inhibitor Development:
8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)is derived from (-)-2β-Carbomethoxy-3β-(4-iodophenyl)nortropane (C176610), which is an inhibitor of the serotonin (5-HT) transporter. As a result, it has potential applications in the development of new inhibitors targeting the serotonin transporter, which could be useful in the treatment of various psychiatric disorders, such as depression and anxiety.
Check Digit Verification of cas no
The CAS Registry Mumber 155797-99-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,5,7,9 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 155797-99:
(8*1)+(7*5)+(6*5)+(5*7)+(4*9)+(3*7)+(2*9)+(1*9)=192
192 % 10 = 2
So 155797-99-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14?,15-,16+,17+/m1/s1
155797-99-2Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-Beta-CIT
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Paragraph 0082; 0083, (2015/03/31)
The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor-β-CIT. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor-β-CIT from anhydroecgonine methyl ester. The invention also relates to the alkylation of a nortropane to the corresponding N-(3-fluoropropyl) analogue using 3-fluoropropanal.
PREPARATION OF N-MONOFLUOROALKYL TROPANES
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Page/Page column 13, (2011/07/07)
The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodides or fluoroalkyl sulfonate esters. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT,
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: Potential positron emission tomography (PET) imaging agents for the dopamine transporter
Gu, Xiao-Hui,Zong, Rushi,Kula, Nora S.,Baldessarini, Ross J.,Neumeyer, John L.
, p. 3049 - 3053 (2007/10/03)
A series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) were determined via competitive binding assays. Among these derivatives, the fluoropropyl ester of β-CIT (19), the fluoroethyl ester of β-CIT (20), the N-fluoropropyl derivative of β-CBT (12), and the fluoropropyl ester of β-CMT (18) displayed higher affinity and greater selectivity for the DAT versus SERT and NET than FP-CIT, which indicates that they are attractive candidates for the development of 18F-labeled PET imaging agents for the DAT.
