46207-56-1Relevant academic research and scientific papers
Radical coupling of arylthiodifluoroacetic acids and ethynylbenziodoxolone (EBX) reagents to access arylthiodifluoromethylated alkynes
Liu, Ya-Ling,Zhu, Xiao-Lei,Huang, Yangen,Qing, Feng-Ling,Xu, Xiu-Hua
, (2020/12/29)
A practical and efficient radical coupling of easily available arylthiodifluoroacetic acids and ethynylbenziodoxolone (EBX) reagents has been reported. Under transition metal-free conditions, aryl-substituted EBXs were converted to the corresponding ArSCF2-substituted alkynes in moderate to good yields, whereas TIPS-EBX underwent silver-catalyzed decarboxylative conditions to deliver the desired coupling products. The synthetic utility of this protocol was demonstrated through the transformation of resulting product to other ArSCF2-substituted alkynes and alkenes.
Catalytic regioselective construction of phenylthio- And phenoxyldifluoroalkyl tetrazoles from difluorodiazoketones
Li, Shuo-Han,Ma, Jun-An,Shi, Hong-Song,Zhang, Fa-Guang
supporting information, p. 13744 - 13747 (2021/12/27)
Here we report the design and synthesis of two new difluoro-diazoketone reagents (difluorophenylthiol diazoketone and difluorophenoxyl diazoketone) and their [3+2] cycloaddition reactions with aryldiazonium salts under silver catalysis conditions. This protocol enables regioselective access to a broad scope of difluorophenylthiol- and difluorophenoxyl-substituted tetrazole-carbinols in a one-pot operation. Further synthetic derivatizations including dephenylthiolation and unexpected phenylthiol group migration/fluorination allow the efficient preparation of α-difluoromethyl tetrazole-carbinols and α-trifluoromethyl tetrazole-thioethers.
Silver-Catalyzed C-H Aryloxydifluoromethylation and Arylthiodifluoromethylation of Heteroarenes
Zhu, Xiao-Lei,Huang, Yangen,Xu, Xiu-Hua,Qing, Feng-Ling
supporting information, p. 5451 - 5455 (2020/07/30)
The oxidative C-H aryloxydifluoromethylation and arylthiodifluoromethylation of heteroaromatic compounds through the decarboxylation of easily accessible aryloxydifluoroacetic acids and arylthiodifluoroacetic acids, respectively, are disclosed. These reac
Direct Regioselective [3 + 2] Cycloaddition Reactions of Masked Difluorodiazoethane with Electron-Deficient Alkynes and Alkenes: Synthesis of Difluoromethyl-Substituted Pyrazoles
Zeng, Jun-Liang,Chen, Zhen,Zhang, Fa-Guang,Ma, Jun-An
supporting information, p. 4562 - 4565 (2018/08/07)
Phenylsulfone difluorodiazoethane (PhSO2CF2CHN2), an easy-to-prepare and bench-stable masked CF2-building block, has been developed. The synthetic utility of this reagent is demonstrated by a direct regioselecti
Fluorodecarboxylation: Synthesis of aryl trifluoromethyl ethers (ArOCF3) and thioethers (ArSCF3)
Krishanmoorthy, Sankarganesh,Schnell, Simon D.,Dang, Huong,Fu, Fang,Prakash, G.K. Surya
, p. 130 - 135 (2017/09/06)
Fluorodecarboxylation of aryloxydifluoroacetic acid (ArOCF2CO2H) and arylmercaptodifluoroacetic acid (ArSCF2CO2H) towards ArXCF3 (X = O, S) using silver (I) salts in the presence of Selectfluor in a biphasic system with trifluoroacetic acid additive is discussed.
COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS
-
Page/Page column 580, (2015/02/02)
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.
Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reactionand desulfanylation
Wu, Jingjing,Li, Hui,Cao, Song
supporting information; experimental part, p. 1070 - 1074 (2011/10/04)
Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel building block 2,2-difluoro-2- (phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of t
