462100-03-4

Basic information

• Product Name: tert-butyl 2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]acetate
• Synonyms: tert-butyl 2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]acetate
• CAS NO: 462100-03-4
• Molecular Weight: 397.469
• Mol File: 462100-03-4.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]acetate(462100-03-4)
• EPA Substance Registry System: tert-butyl 2-[2-[2-[2-(benzyloxycarbonylamino)ethoxy]ethoxy]ethoxy]acetate(462100-03-4)

Safety Data

• Hazardous Substances Data: 462100-03-4(Hazardous Substances Data)

Upstream product

• 145881-74-9 2-<2-N-(benzyloxycarbonyl)aminoethoxy>ethanol 
• 501-53-1 benzyl chloroformate 
• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 205535-92-8 2-[2-{2-(N-benzyloxycarbonyl)aminoethoxy}ethoxy]ethanol 

Downstream Products

• 462100-05-6 2-[2-{2-(N-benzyloxycarbonyl)aminoethoxy}ethoxy]ethoxyacetic acid 

Relevant articles and documents

PROTAC-mediated crosstalk between E3 ligases

Small-molecule heterobifunctional degraders can effectively control protein levels and are useful research tools. We assembled proteolysis targeting chimeras (PROTACs) from a cereblon (CRBN) and a von-Hippel-Lindau (VHL) ligase ligand and demonstrated a PROTAC-induced heterodimerization of the two E3 ligases leading to unidirectional and efficient degradation of CRBN.