46225-45-0

Upstream product

• 638-21-1 phenylphosphane 
• 110-83-8 cyclohexene 
• 644-97-3 Dichlorophenylphosphine 
• 931-50-0 cyclohexylmagnesium bromide 
• 75354-35-7 (±)-cyclohexyl(phenyl)phosphine oxide 
• 953-91-3 cyclohexyl tosylate 
• 542-18-7 cyclohexyl chloride 

Downstream Products

• 110410-45-2 N-Methyl-1-(cyclohexyl-phenylphosphino)thioformamid 
• 139936-95-1 4-(Cyclohexyl-phenyl-phosphanyl)-butyronitrile 
• 638166-55-9 (cyclohexyl)phenylphosphine-borane 
• 1345043-28-8 (R,S)-2-(cyclohexylphenylphosphino-borane)-2'-methoxy-1,1'-binaphthyl 
• 1345043-28-8 (R,R)-2-(cyclohexylphenylphosphino-borane)-2'-methoxy-1,1'-binaphthyl 
• 1346107-78-5 (R,S)-2-(cyclohexylphenylphosphino)-2'-methoxy-1,1'-binaphthyl 
• 1345043-28-8 (R)-2-(cyclohexylphenylphosphinoborane)-2'-methoxy-1,1'-binaphthyl 
• 108609-43-4 C₁₉H₂₃P 
• 108609-43-4 C₁₉H₂₃P 
• 57109-28-1 {Rh(PHCyPh)4}ClO₄ 

Relevant academic research and scientific papers

Nucleophilic Substitution with Phosphide Anions Prepared by an Action of Sodium Dihydridobis(2-methoxyethanolato)aluminate on Phosphorus Compounds

Phosphide anions, prepared by an action of sodium dihydridobis(2-methoxyethanolato)aluminate on derivatives of phosphine, phosphine oxide, or phosphorus esters, react with primary and secondary alkyl halides to produce phosphine derivatives having a newly formed phosphorus-carbon bond.The reactivity increases in the order of chloride N2 type process.

Ni-Catalyzed Asymmetric Hydrophosphination of Unactivated Alkynes

The practical synthesis of P-stereogenic tertiary phosphines, which have wide applications in asymmetric catalysis, materials, and pharmaceutical chemistry, represents a significant challenge. A regio- and enantioselective hydrophosphination using cheap a

Ln(ii) amido complexes coordinated by ring-expanded N-heterocyclic carbenes-promising catalysts for olefin hydrophosphination

First Ln(ii) ring-expanded NHC complexes (er-NHC)Ln[N(SiMe3)2]2 (Ln = Sm, Yb) are synthesized and proved to be highly efficient pre-catalysts for the intermolecular hydrophosphination of such indolent substrates as 1-alkenes, cyclohexene and norbornene. This journal is

The synthesis of P-stereogenic MOP analogues and their use in rhodium catalysed asymmetric addition

The synthesis is reported of novel P-stereogenic binaphthyl substituted monophosphines via a short five-step synthesis using a nickel coupling reaction with separation of the borane-protected diastereomeric products. Extensive coordination studies of these ligands with a number of well-known metal precursors were performed to more effectively understand their behaviour during catalysis. These ligands and some previously reported P-stereogenic ligands were tested in the rhodium catalysed asymmetric addition of phenyl boronic acid to napthaldehyde. These studies in asymmetric catalysis were used to compare the chiral induction of ligands that combine both axial and central chirality with ligands lacking P-stereogenicity.

A straightforward synthesis of unsymmetrical secondary phosphine boranes

A one-pot procedure for the synthesis of unsymmetrical alkyl-substituted secondary phosphine oxides is described. The sequential addition of N-benzylaniline to a solution of dichlorophenylphosphine and 1-methylimidazole in methylcyclohexane, separating of the protic ionic liquid formed, addition of Grignard reagent followed by hydrolysis gave unsymmetrical secondary phosphine oxides (SPOs) in high yield. The use of ionic liquids in the first step is essential and streamlined the synthesis. Unsymmetrical SPOs could be quantitatively reduced to secondary phosphine using a catalytic amount of Ti(OiPr)4 and tetramethyldisiloxane (TMDS) under mild reaction conditions.

A METHOD FOR GENERATING SECONDARY PHOSPHINES

This invention provides a method for generating secondary phosphines from secondary phosphine oxides in the presence of a reducing agent, such as diisobutylaluminum hydride (DIBAL-H), triisobutyldialuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, or another reducing agent comprising: (i) an R1R2AIH moiety, wherein R1 and R2 are each an alkyl species or oxygen, and wherein at least one of R1 or R2 comprises at least 2 carbon atoms, or (ii) an R1R2R3AI moiety, wherein R1, R2, and R3 are not hydrogen, and wherein at least one of R1, R2, and R3 is an alkyl species comprising a β-hydrogen, not including triethylaluminum. Preferred reducing agents for the present invention include: diisobutylaluminum hydride, triisobutyldialiuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, and combinations thereof.