46246-91-7

Usage

Uses

Used in Medicinal Chemistry and Drug Development:
6-Benzyl-2-oxa-6-azaspiro[3.3]heptane is utilized as a central nervous system depressant, leveraging its potential anticonvulsant and anxiolytic properties. Its unique structure and biological activities make it a promising candidate for the development of new therapeutic agents targeting neurological disorders.
Used in Organic Chemistry as a Synthetic Intermediate:
Due to its spirocyclic structure, 6-benzyl-2-oxa-6-azaspiro[3.3]heptane serves as a valuable synthetic intermediate in organic chemistry. It facilitates the creation of complex molecules with a range of pharmacological properties, contributing to the advancement of chemical synthesis and the discovery of novel compounds with therapeutic potential.

InChI:InChI=1/C12H15NO/c1-2-4-11(5-3-1)6-13-7-12(8-13)9-14-10-12/h1-5H,6-10H2

Upstream product

• 2402-83-7 3,3-bis(bromomethyl)oxetane 
• 100-46-9 benzylamine 
• 1522-92-5 2,2-bis(bromomethyl)-3-bromo-propan-1-ol 
• 78-71-7 3,3-bis(chloromethyl)oxetane 

Downstream Products

• 174-78-7 2-oxa-6-azaspiro[3.3]heptane 
• 1159599-99-1 2-oxa-6-azaspiro[3.3]heptan-6-ium carboxyformate 

Relevant academic research and scientific papers

Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts

An improved synthesis of the bicyclic spiro compound 2-oxa-6-azaspiro[3.3]heptane is presented. While this compound is often isolated as an oxalate salt, its isolation as a sulfonic acid salt yields a more stable and more soluble product. With these improved properties access to a wider range of reaction conditions with the spirobicyclic 2-oxa-6-azaspiro[3.3]heptane has been enabled.

The Development of a Manufacturing Route to an MCHr1 Antagonist

Process development work to provide an efficient manufacturing route to a MCHr1 antagonist is presented herewith. Features of this development work include a scalable manufacturing route to the useful 6-oxa-2-azaspiro[3.3]heptane building block and the use of a (soluble) alternative to sodium triacetoxyborohydride.