2942-54-3

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 122-52-1 triethyl phosphite 
• 112579-84-7 diethyl [amino(4-methylphenyl)methyl]phosphonate 
• 99-94-5 p-Toluic acid 
• 96258-65-0 diethyl α-trimethylsilyloxy-4-methylbenzylphosphonate 
• 78-40-0 triethyl phosphate 
• 201230-82-2 carbon monoxide 
• 106-38-7 para-bromotoluene 
• 762-04-9 phosphonic acid diethyl ester 
• 624-31-7 4-tolyl iodide 
• 104-87-0 4-methyl-benzaldehyde 
• 79158-40-0 diethyl hydroxy(p-tolyl)methylphosphonate 

Downstream Products

• 64196-49-2 Phosphorsaeure-1-(diethoxyphosphinyl)-(4-methylphenyl)-methyl-diethylester 
• 41993-27-5 2,2-diphenyl-1-p-tolylethanone 
• 4625-47-2 1-hydroxy-1,1-diphenyl-2-(4-methylphenyl)ethan-2-one 
• 3449-99-8 diethyl 1-(benzoyloxy)-1-phenylmethylphosphonate 
• 1307916-33-1 diethyl 1-hydroxy-1-p-tolylprop-2-ynylphosphonate 
• 1315552-53-4 (R)-diethyl [1-hydroxy-1-(4-methylphenyl)3-oxopropyl]phosphonate 
• 174678-80-9 diethyl [(4-α-bromomethyl)phenyldifluoromethyl]-phosphonate 
• 1408232-37-0 C₂₀H₂₂F₂N₃O₃P 
• 1408232-42-7 C₁₆H₁₄F₂N₃O₃P 
• 1408232-39-2 C₂₄H₂₄F₂N₃O₃P 
• 1408232-38-1 C₂₀H₁₆F₂N₃O₃P 
• 185965-95-1 (difluoro-p-tolylmethyl)phosphonic acid diethyl ester 
• 1513846-35-9 diethyl ((2S,3S)-5-oxo-3-phenyl-2-(p-tolyl)tetrahydrofuran-2-yl)phosphonate 

Relevant academic research and scientific papers

A convenient and mild protocol for preparation of α – trimethylsilyloxyphosphonates using sulfamic acid and their oxidation to α – ketophosphonates in the presence of N-bromosuccinimide

A convenient and mild protocol was developed for the trimethylsilylation of α-hydroxyphosphonates using hexamethyldisilazane as the silylating agent in the presence of sulfamic acid (SA) as a heterogeneous solid acid catalyst in dichloromethane as the rea

Enantioselective vinylogous aldol reaction of acylphosphonates with 3-alkylidene oxindoles

A simple strategy for yielding chiral tertiary α-hydroxy phosphonates that integrates two highly biologically relevant scaffolds namely 3-alkylidene-2-oxindoles and phosphonates has been described. The hydrogen bonding ability of the bifunctional thiourea catalyst allows simultaneous dual activation of a vinylogous oxindole nucleophile and an acylphosphonate electrophile, affording hydroxyphosphonato-3-alkylidene-2-oxindoles as aldol adducts in high yields (up to 92%) with excellent stereocontrol (up to 99% ee).

Highly efficient and extremely simple protocol for the oxidation α-hydroxyphosphonates to α-ketophosphonates using Dess-Martin periodinane

Dess-Martin periodinane has been demonstrated for the first time to be an efficient reagent in metal - free oxidation of α-hydroxyphosphonates to α-ketophosphonates under ambient conditions. Acquiescent reaction conditions and a simple isolation procedure

Visible photocatalysis of novel oxime phosphonates: Synthesis of β-aminophosphonates

A novel type of oxime phosphonate was synthesized and used in the intermolecular cascade radical addition reaction of alkenes to access β-aminophosphonates via visible-light-driven N-centered iminyl radical-mediated and redox-neutral selective C-P single-bond cleavage in an active phosphorus radical route. The procedure is characterized by its ability to achieve the construction of Csp3-P and Csp3-N bonds without the requirement for oxidants and bases.

Carbene-catalyzed enal γ-carbon addition to α-ketophosphonates for enantioselective access to bioactive 2-pyranylphosphonates

A carbene-catalyzed enantioselective [4+2] cycloaddition reaction between α,β-unsaturated aldehydes and α-ketophosphonates is developed. The reaction affords chiral 2-pyranylphosphonates with excellent enantioselectivities. The optically enriched phosphonate products bear multiple functional groups, including unsaturated lactone and phosphonate moieties that often lead to unique bio-activities. Preliminary studies show that the products from our reactions exhibit anti-bacterial (X. oryzae pv. oryzae) and anti-viral (Tobacco Mosaic Virus) activities for potential use in plant protection.

Catalytic Aldol-Cyclization Cascade of 3-Isothiocyanato Oxindoles with α-Ketophosphonates for the Enantioselective Synthesis of β-Amino-α-hydroxyphosphonates

A cascade aldol-cyclization reaction between 3-isothiocyanato oxindoles and α-ketophosphonates has been developed for the synthesis of β-amino-α-hydroxyphosphonate derivatives. Catalyzed by a quinine-based tertiary amino-thiourea derivative, this reaction

Pd-catalyzed carbonylative access to aroyl phosphonates from (hetero)aryl bromides

The first transition-metal catalysed carbonylation with a phosphorus nucleophile is presented. This transformation provides efficient and mild access to aroylphosphonates under mild conditions, thus ensuring a broad substrate scope. The utility of aroylph

Synthesis of acylphosphonates by a palladium-catalyzed phosphonocarbonylation reaction of aryl iodides with phosphites

Acylphosphonates are conveniently synthesized from aryl iodides by a palladium-catalyzed reaction with dialkyl phosphites under an atmospheric pressure of carbon monoxide. The reaction demonstrates the first example of the use of phosphorus nucleophiles in related metal-catalyzed carbonylation reactions.

Asymmetric homoenolate additions to acyl phosphonates through rational design of a tailored N-heterocyclic carbene catalyst

A highly selective NHC-catalyzed synthesis of γ-butyrolactones from the fusion of enals and α-ketophosphonates has been developed. Computational modeling of competing transition states guided a rational design strategy to achieve enhanced levels of enanti

Rational design of selective organoruthenium inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases (PTPs) belong to a large family of important regulatory enzymes involved in vital mammalian signaling pathways. Selective inhibitors of PTPs are highly valuable from a therapeutic standpoint given their association with various pathological conditions. One such target is PTP-1B which has previously been linked to diabetes and cancer. However, developing a selective inhibitor against PTP-1B has proven to be daunting because the enzyme shares a high degree of structural homology with TC-PTP, an essential PTP involved in modulating immune functions. To address this challenge, a series of organoruthenium complexes was developed to bind at the PTP substrate-binding site while simultaneously target the peripheral structural space. By capitalizing on the potential difference in the structural environment proximal to the active site between different PTPs, selectivity toward PTP-1B over TC-PTP was improved, paving the way for organoruthenium complexes as selective PTP-1B metalloinhibitors.