46313-35-3Relevant academic research and scientific papers
Efficient and benign one-pot conversion of n-tosyl-1,4,5,6- tetrahydropyrimidines to pyrimidines via tandem β-elimination and aromatization
Trieu, Tien Ha,Dong, Jing,Shi, Xiao-Xin,Lu, Xia,Zhang, Qiang
, p. 3141 - 3152 (2014/01/06)
An efficient, mild, benign, and practical method for one-pot conversion of N-tosyl-1,4,5,6-tetrahydropyrimidines into pyrimidines is discussed in detail. In this method, N-tosyl-1,4,5,6-tetrahydropyrimidines are first prepared via N-tosylation of tetrahyd
Ecofriendly synthesis of tetrahydropyrimidine derivatives in aqueous medium under ultrasonic irradiation
Koteswara Rao, Valasani,Hari Babu, Boppudi,Raveendra Babu, Kilaru,Srinivasulu, Doddaga,Naga Raju, Chamarthi
experimental part, p. 3368 - 3376 (2012/09/08)
A simple, efficient, and ecofriendly procedure was developed for the synthesis of 2-substituted 1,4,5,6-tetrahydropyrimidine derivatives catalyzed by N-bromosuccinimide using ultrasonic irradiation in aqueous medium. Prominent advantages of this new method are good yields, aqueous medium, short reaction times, and easy workup procedure. The compounds were characterized by infrared, NMR, liquid chromatography-mass spectrometry, and elemental analyses.
Cu(ii)-mediated oxidative intermolecular ortho C-H functionalisation using tetrahydropyrimidine as the directing group
Mizuhara, Tsukasa,Inuki, Shinsuke,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
supporting information; experimental part, p. 3413 - 3415 (2009/12/26)
Tetrahydropyrimidine works efficiently as a directing group in Cu(ii)-mediated oxidative aromatic C-H functionalisation for the selective introduction of oxygen or nitrogen to the ortho-position.
