46331-24-2

Upstream product

• 122-79-2 Phenyl acetate 
• 98-67-9 p-hydoroxybenzenesulfonic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 1119833-23-6 4-(N-(2-methoxybenzyl)sulfamoyl)phenyl acetate 
• 79119-26-9 4-acetoxybenzenesulfonyl chloride 

Relevant academic research and scientific papers

Efficient synthesis and reaction kinetics of readily water soluble esters containing sulfonic groups

A series of various readily water soluble esters were synthesized by a very efficient procedure. These compounds can be useful as thermosensitive tracers for studying the cooling progress in a low enthalpy georeservoir exploitable by double flash geothermal power plant systems. The kinetics of their hydrolysis was investigated. Acylation of primary alcohols or phenols was carried out by a method based on a single-phase solvent system consisting of ethyl acetate acting as an organic solvent and triethylamine acting as a catalyst. Products were characterized by 1H-NMR, and 13C-NMR.

Reactions of sulfur trioxide with benzene derivatives containing a deactivating oxy substituent

The reactions of phenyl acetate (2), (trifluoromethoxy)benzene (3), (difluoromethoxy)benzene (4), 4-(trifluoromethoxy)phenol (5), 4-(trifluoromethoxy)phenyl methanesulfonate (6), 4-(trifluoromethoxy)anisole (7) and 3-(trifluoromethoxy)anisole (8) with SO3 in nitromethane have been studied.Upon reaction with SO3, 2 yields 2-4-sulfonic acid (2-4-S); subsequently, transfer of the acetyl group takes place to yield the mixed anhydride of phenol-4-pyrosulfonic acid and acetic acid (9) or the corresponding hydrogen sulfate 10, depending on the amount of SO3 used.Reaction of the α-fluorinated anisoles 3 and 4 with SO3 leads to sulfonation at the 4-position only; however, on using both a high substrate concentration and an excess of SO3, some 2,4-S2 is formed with 4 but not with 3.On reaction of 5 with 0.8 mol-equiv of SO3 in C(2)H3NO2, the hydrogen sulfate derivative (5-O-S) is formed; at 100 deg C, some isomerization to 5-2-S occurs.Upon reaction with 4.0 mol-equiv of SO3, the initially formed hydrogen sulfate slowly yields the corresponding 2-sulfophenyl hydrogen sulfate (5-O,2-S2).On using 6.0 mol-equiv of SO3, the 5-O,2-S2 is slowly converted into 6-(trifluoromethoxy)benzo-1,3,2,4-dioxadithiin 2,2,4,4-tetraoxide (11).Reaction of 6 with either 0.9 or 3.0 mol-equiv of SO3, initially leads to insertion of sulfur trioxide in between the SO2CH3 and the adjacent O, yielding the 4-(trifluoromethoxy)phenyl methanepyrosulfonate 12.This species subsequently yields 13 and 14.Reaction of 7 with SO3 leads to sulfonation only at the 2-position; eventually some sulfodemethylation to yield 5-2-S takes place.Reaction of 8 with 1.0 mol-equiv of SO3 yields a 68:32 mixture of 8-4-S and 8-6-S.