463336-07-4

Basic information

• Product Name: 5-BROMO-2-(4-FLUOROPHENYL)PYRIDINE
• Synonyms: 5-BROMO-2-(4-FLUOROPHENYL)PYRIDINE
• CAS NO: 463336-07-4
• Molecular Formula: C₁₁H₇BrFN
• Molecular Weight: 252.09
• Mol File: 463336-07-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 74-75 °C
• Boiling Point: 306.957°C at 760 mmHg
• Flash Point: 139.443°C
• Appearance: /
• Density: 1.497g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Room temperature.
• PKA: 2.15±0.25(Predicted)
• CAS DataBase Reference: 5-BROMO-2-(4-FLUOROPHENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-(4-FLUOROPHENYL)PYRIDINE(463336-07-4)
• EPA Substance Registry System: 5-BROMO-2-(4-FLUOROPHENYL)PYRIDINE(463336-07-4)

Safety Data

• Hazardous Substances Data: 463336-07-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-(4-fluorophenyl)pyridine is a chemical compound that belongs to the class of organic compounds known as pyridines and derivatives. It has a molecular formula of C11H7BrFN and a molecular weight of 256.084 g/mol. The compound is characterized by a pyridine ring, which is a six-membered heterocyclic ring with five carbon atoms and one nitrogen atom. As indicated by its name, the compound contains bromine and fluorine atoms, which are attached to the pyridine ring along with a phenyl group. Significant in various chemical reactions and syntheses, it possesses properties typical of aromatic compounds and halogenated compounds. Its precise toxicity and potential uses in different industries or research fields may vary and would depend on further scientific investigations.

InChI:InChI=1/C11H7BrFN/c12-9-3-6-11(14-7-9)8-1-4-10(13)5-2-8/h1-7H

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 437-29-6 tris(4-fluorophenyl)bismuthane 
• 223463-13-6 2-iodo-5-bromopyridine 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 1037829-64-3 3-[6-(4-fluoro-phenyl)-pyridin-3-yl]-acrylic acid ethyl ester 
• 58861-53-3 4-fluorophenylpyridine 
• 1333171-10-0 (6S)-6-({3-[6-(4-fluorophenyl)-3-pyridinyl]-2-propynyl}oxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 

Relevant articles and documents

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

A study on the selectivity of arylzinc reagents in cross-coupling reactions with chemically equivalent and pseudo-equivalent dibromopyridines

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Synthesis and structure-activity relationships of varied ether linker analogues of the antitubercular drug (6 S)-2-nitro-6-{[4-(trifluoromethoxy) benzyl]oxy}-6,7-dihydro-5 H -imidazo[2,1- b ][1,3]oxazine (PA-824)

New analogues of antitubercular drug PA-824 were synthesized, featuring alternative side chain ether linkers of varying size and flexibility, seeking drug candidates with enhanced metabolic stability and high efficacy. Both α-methyl substitution and removal of the benzylic methylene were broadly tolerated in vitro, with a biaryl example of the latter class exhibiting an 8-fold better efficacy than the parent drug in a mouse model of acute Mycobacterium tuberculosis infection and negligible fragmentation to an alcohol metabolite in liver microsomes. Extended linkers (notably propenyloxy, propynyloxy, and pentynyloxy) provided greater potencies against replicating M. tb (monoaryl analogues), with propynyl ethers being most effective under anaerobic (nonreplicating) conditions (mono/biaryl analogues). For benzyloxybenzyl and biaryl derivatives, aerobic activity was maximal with the original (OCH2) linker. One propynyloxy-linked compound displayed an 89-fold higher efficacy than the parent drug in the acute model, and it was slightly superior to antitubercular drug OPC-67683 in a chronic infection model.