46352-82-3Relevant academic research and scientific papers
Efficient and controllably selective preparation of esters using uronium-based coupling agents
Twibanire, Jean-D'Amour K.,Grindley, T. Bruce
supporting information; experimental part, p. 2988 - 2991 (2011/08/04)
Carboxylic acid esters can be prepared in excellent yields at room temperature from an acid and either a phenol or an aliphatic alcohol using the peptide coupling reagents, TBTU, TATU, or COMU, in the presence of organic bases. Reactions using TBTU and TATU are faster but do not occur with tertiary alcohols. Selectivity between reaction with primary or secondary alcohols in diols and polyols can be achieved with choice of base and coupling agent.
