29639-77-8

Basic information

• Product Name: 2-(4-Iodo-phenoxy)-ethanol
• Synonyms: 2-(4-Iodo-phenoxy)-ethanol
• CAS NO: 29639-77-8
• Molecular Formula: C₈H₉IO₂
• Molecular Weight: 264.06033
• Mol File: 29639-77-8.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Iodo-phenoxy)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Iodo-phenoxy)-ethanol(29639-77-8)
• EPA Substance Registry System: 2-(4-Iodo-phenoxy)-ethanol(29639-77-8)

Safety Data

• Hazardous Substances Data: 29639-77-8(Hazardous Substances Data)

Usage

Physical state

Clear, colorless liquid It is a liquid without any color, and the clarity allows light to pass through it.

Odor

Slightly phenolic It has a mild smell similar to that of phenol, but not as strong.

Usage

Solvent and intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds It is used as a medium to dissolve substances and facilitate chemical reactions in the production of various products.

Hazardous nature

Different sources of media describe the Hazardous nature of 29639-77-8 differently. You can refer to the following data:
1. Skin and eye irritation Contact with the skin or eyes may cause irritation or damage.
2. Harmful if swallowed or inhaled Ingesting or breathing in 2-(4-Iodo-phenoxy)-ethanol can lead to adverse health effects.

Precautions

Appropriate safety measures should be taken when handling and using Due to its hazardous nature, it is essential to follow safety guidelines and use protective equipment when working with this chemical.

Upstream product

• 122-99-6 2-Phenoxyethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 540-38-5 p-Iodophenol 
• 1249719-13-8 C₈H₇IO₂ 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 

Downstream Products

• 690265-95-3 2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-ethanol 
• 866929-94-4 2-{4-[5-(4-chloro-phenyl)-3-fluoro-pyridin-2-ylethynyl]-phenoxy}-ethanol 
• 866929-90-0 2-(4-trimethylsilanylethynyl-phenoxy)-ethanol 
• 866928-31-6 1-(2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-ethyl)-4-trifluoromethyl-piperidin-4-ol 
• 690265-96-4 methanesulfonic acid-2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy} ethyl ester 
• 67856-41-1 1-iodo-4-(2-iodoethoxy)benzene 
• 1333170-82-3 (6S)-2-nitro-6-(2-{4-[6-trifluoromethyl-3-pyridinyl]phenoxy}ethoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 
• 1333170-81-2 (6S)-2-nitro-6-(2-{[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy}ethoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 
• 1333170-80-1 (6S)-6-{2-[(4'-fluoro[1,1'-biphenyl]-4-yl)oxy]ethoxy}-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 
• 1333170-79-8 (6S)-2-nitro-6-(2-{[4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]oxy}ethoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 
• 1333171-31-5 (6S)-6-[2-(4-iodophenoxy)ethoxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 

Relevant articles and documents

Design, synthesis and evaluation of MCH receptor 1 antagonists - Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414

Abstract Despite recent approvals of anti-obesity drugs there is still a high therapeutic need for alternative options with higher efficacy in humans. As part of our MCH-R1 antagonist program for the treatment of obesity, a series of biphenylacetamide HTS

The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy)caffeine analogues

Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an IC 50 value of 0.383M towards MAO-B. In an attempt to improve on the inhibition potency of this compound and to discover highly potent reversible MAO-B inhibitors, in the present study, a series of 8-(2-phenoxyethoxy)caffeine analogues containing various substituents on C4 of the phenoxy ring, were synthesized and evaluated as inhibitors of human MAO-A and -B. The results show that the 8-(2-phenoxyethoxy)caffeine analogues are selective and reversible MAO-B inhibitors with the most potent homologue, 8-{2-[4-(trifluoromethyl) phenoxy]ethoxy}caffeine, exhibiting an IC50 value of 0.061μM. These highly potent inhibitors are useful leads in the design of therapies for neurodegenerative disorders such as Parkinsons disease. Georg Thieme Verlag KG Stuttgart New York.

NEW PYRIDAZINE DERIVATIVES WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS

The present invention relates to compounds of general formula I wherein the groups and radicals B, W, X, Y, Z, R1, R2, have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.