46394-28-9

Basic information

• Product Name: 1-Propanone, 3-(dimethylamino)-1-(2-methoxyphenyl)-
• CAS NO: 46394-28-9
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.272
• Mol File: 46394-28-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-(dimethylamino)-1-(2-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-(dimethylamino)-1-(2-methoxyphenyl)-(46394-28-9)
• EPA Substance Registry System: 1-Propanone, 3-(dimethylamino)-1-(2-methoxyphenyl)-(46394-28-9)

Safety Data

• Hazardous Substances Data: 46394-28-9(Hazardous Substances Data)

Usage

Type

Synthetic cathinone

Classification

Stimulant, entactogen

Chemical relation

Related to cathinone, a stimulant found in the khat plant

Legal status

Controlled substance in many countries

Effects

Euphoria, increased heart rate, elevated blood pressure, changes in perception and mood, feelings of empathy and emotional openness, increased energy

Long-term use risks

Adverse effects on mental and physical health, potential for abuse and addiction.

Upstream product

• 1776-12-1 1-(2-methoxyphenyl)prop-2-yn-1-ol 
• 135-02-4 ortho-anisaldehyde 
• 1776-13-2 1-(2-methoxyphenyl)-2-propyn-1-one 
• 124-40-3 dimethyl amine 
• 646-06-0 1,3-DIOXOLANE 
• 579-74-8 2-Methoxyacetophenone 
• 506-59-2 N,N-dimethylammonium chloride 
• 50-00-0 formaldehyd 

Downstream Products

• 77942-10-0 1-(2-methoxyphenyl)prop-2-en-1-one 
• 653573-47-8 [3-(2-methoxy-phenyl)-3-(naphthalen-1-yloxy)-propyl]-dimethyl-amine 
• 16931-75-2 2-<β-(o-Methoxybenzoyl)-aethyl>-cyclopentanon 
• 167642-42-4 1-(2'-methoxyphenyl)-4-nitro-1-butanone 

Relevant articles and documents

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.

NOVEL 5-HT2 ANTAGONISTS

The present invention relates to 1-amidino-3-aryl-2-pyrazoline derivatives of the general formula I The invention specifically relates to such derivatives which exhibit antagonizing activity towards serotonin 5-HT2B receptors. The present invention also relates to use of said compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases, as well as pharmaceutical compositions comprising one or more of said compounds and methods of treatment.

UROTENSIN II RECEPTOR MODULATORS

Disclosed are compounds of Formula I, or salts or prodrugs thereof, complexed with a human urotensin II receptor as defined herein. Also disclosed are compounds of Formula II, or salts or prodrugs thereof, as defined herein. Also disclosed are methods of modulating the activity of a urotensin II receptor using a compound of Formula I, or a compound of Formula II, or salts or prodrugs thereof. In addition, methods of treating diseases related to the activity of urotensin II receptors are disclosed.