4646-80-4

Usage

Uses

Used in Flavor and Fragrance Industry:
(1E)-1-phenylhex-1-en-3-one is utilized as a flavoring agent and fragrance, capitalizing on its appealing aroma to enhance the sensory experience of food and perfumery products. Its sweet and floral scent profile with a fruity undertone allows it to contribute positively to the overall smell and taste of these products.
Used in Pharmaceutical Production:
In the pharmaceutical sector, (1E)-1-phenylhex-1-en-3-one serves as a synthetic intermediate. It plays a crucial role in the synthesis of various pharmaceuticals and organic compounds, facilitating the development of new medications and contributing to advancements in healthcare.
However, it is imperative to exercise caution and adhere to safety guidelines when handling (1E)-1-phenylhex-1-en-3-one due to its potential health hazards, ensuring that its benefits are realized without compromising safety.

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 100-52-7 benzaldehyde 
• 107-87-9 2-Pentanone 
• 25016-92-6 aluminium triisopentylate 
• 1071027-85-4 3-Ethoxy-1-phenyl-hexa-1,2-dien 
• 629-27-6 1-Iodooctane 
• 102-92-1 cinnamoyl chloride 
• 1078127-06-6 1-phenyl-1-phenylselenohexan-3-one 
• 7579-98-8 diethyl pent-1-ynylphosphonate 
• 27975-66-2 3-Ethoxy-1-phenyl-hex-1-in 

Downstream Products

• 29898-25-7 1-phenylhexan-3-one 
• 4909-19-7 1,1-di(p-tolyl)pentan-3-one 
• 1280725-60-1 1-phenyl-1-p-tolylhexan-3-one 
• 1280725-55-4 (R)-1-phenyl-1-p-tolylhexan-3-one 
• 1315340-12-5 (S)-ethyl 2-methylene-5-oxo-3-phenyloctanoate 
• 1397692-25-9 (5S,6S,7R,10S)-ethyl 7-ethyl-4,8-dioxo-3,10-diphenyl-2-thioxo-1-thia-3-azaspiro[4.5]decane-6-carboxylate 
• 1397692-26-0 (5S,6S,7R,10S)-6-(4-bromophenyl)-7-ethyl-3,10-diphenyl-2-thioxo-1-thia-3-azaspiro[4.5]decane-4,8-dione 

Relevant academic research and scientific papers

Facile Synthesis of Polysubstituted 2-Pyrones via TfOH-Mediated Ring Expansion of 2-Acylcyclopropane-1-carboxylates

A facile route to polysubstituted 2-pyrones from readily available 2-acylcyclopropane-1-aryl-1-carboxylates mediated by TfOH is reported. The strongly donating 1-aryl group is important for directing the C-C bond cleavage of the donor-acceptor cyclopropane ring, which then leads to the formation of the 2-pyrone ring through lactonization.

Enzyme-catalyzed domino reaction: Efficient construction of spirocyclic oxindole skeleton using porcine pepsin

Pepsin from porcine gastric mucosa was used as a sustainable and environmentally friendly biocatalyst in the domino Knoevenagel/Michael/Michael reaction for the synthesis of spirooxindole derivatives in methanol. A wide range of isatins and α,β-unsaturated ketones reacting with malononitrile provided the corresponding products in yields of up to 99% with diastereoselectivities of up to >99:1 dr. This pepsin-catalyzed domino reaction provided a novel case of enzyme catalytic promiscuity.

Sequential aldol Condensation-Transition metal-Catalyzed addition reactions of aldehydes, methyl ketones, and arylboronic acids

Sequential aldol condensation of aldehydes with methyl ketones followed by transition metal-catalyzed addition reactions of arylboronic acids to form β-substituted ketones is described. By using the 1,1′;-spirobiindane- 7,7′;-diol (SPINOL)-based phosphite, an asymmetric version of this type of sequential reaction, with up to 92% ee, was also realized. Our study provided an efficient method to access β-substituted ketones and might lead to the development of other sequential/tandem reactions with transition metal-catalyzed addition reactions as the key step.

Reaction behavior of cyclopropylmethyl cations derived 1-phenylselenocyclopropylmethanols with acids

The 1-phenylselenocyclopropylmethyl cations are generated by the reaction of the corresponding cyclopropylmethanols 1 with TsOH. The reaction in methanol proceeds to afford the homoallylic ethers 2, ring-enlargement products 3, 4, and ring opening product

Process for separating zinc salts from zinc alcoholates or zinc amides containing non-aqueous synthesis solvents

A process for the removal of zinc from organic solutions containing zinc alcoholates or zinc amides comprises addition of an alkylating, arylating, acylating or silylating agent in the presence of a precipitating agent having at least two nitrogen donors followed by separation of the precipitated solid.

A Convenient and Efficient Unsymmetrical Ketone Synthesis from Acid Chlorides and Alkyl Iodides Catalyzed by Palladium

Unsymmetrical ketones are prepared in good or excellent yields by a palladium catalyzed coupling reaction of acid chlorides and alkyl iodides meditated by Zn-Cu couple.

ALDOL CONDENSATIONS WITH METAL(II) COMPLEX CATALYSTS.

Aldol condensations of aldehydes with ketones catalyzed by the first-row transition metal(II) complexes have been widely studied. Complexes of Co(II), Ni(II), Cu(II), and Zn(II) acetates with 2,2 prime -bypyridine were effective catalysts to afford cross-aldol condensation products, alpha , beta ,-unsaturated ketones, in high yields without any self-condensation products. The reaction of 2-butanone, unsymmetrical aliphatic ketone, with benzaldehyde took place regioselectively to give base-catalyzed-type products.