4651-73-4

Basic information

• Product Name: 2-AMINO-4-PHENYL-3-THIOPHENECARBONITRILE
• Synonyms: 2-AMINO-4-PHENYL-3-THIOPHENECARBONITRILE;AKOS MSC-0415;2-aMino-4-phenylthiophene-3-carbonitrile
• CAS NO: 4651-73-4
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.26
• Mol File: 4651-73-4.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-AMINO-4-PHENYL-3-THIOPHENECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-PHENYL-3-THIOPHENECARBONITRILE(4651-73-4)
• EPA Substance Registry System: 2-AMINO-4-PHENYL-3-THIOPHENECARBONITRILE(4651-73-4)

Safety Data

• Hazardous Substances Data: 4651-73-4(Hazardous Substances Data)

Usage

General Description

2-Amino-4-phenyl-3-thiophenecarbonitrile is a chemical compound with the molecular formula C11H8N2S and a molecular weight of 204.27 g/mol. It is a thiophene-based organic compound that contains an amino group, a phenyl group, and a cyano group. 2-AMINO-4-PHENYL-3-THIOPHENECARBONITRILE is commonly used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. It is also utilized in the development of organic semiconductors and materials used in electronic devices. The compound's structural properties and functional groups make it a versatile and valuable component in the field of organic chemistry.

Upstream product

• 5447-87-0 2-(1-phenylethylidene)propanedinitrile 
• 98-86-2 acetophenone 
• 109-77-3 malononitrile 
• 100-52-7 benzaldehyde 

Downstream Products

• 85487-08-7 2-acetamido-3-cyano-4-phenylthiophene 
• 100005-18-3 4-Phenyl-2-p-tolylamino-thiophene-3-carbonitrile 
• 100005-19-4 2-(4-Methoxy-phenylamino)-4-phenyl-thiophene-3-carbonitrile 
• 85934-25-4 2-amino-3-cyano-4-phenyl-5-phenylazothiophene 
• 1375399-07-7 9-imino-4-oxo-3-phenyl-7-(p-tolyl)-5,9-dihydro-4H-pyrido[1,2-a]thieno[3,2-e]pyrimidine-6,8-dicarbonitrile 
• 1375399-10-2 9-imino-7-(4-methoxyphenyl)-4-oxo-3-phenyl-5,9-dihydro-4H-pyrido[1,2-a]thieno[3,2-e]pyrimidine-6,8-dicarbonitrile 
• 1375399-13-5 9-imino-7-(4-nitrophenyl)-4-oxo-3-phenyl-5,9-dihydro-4H-pyrido[1,2-a]thieno[3,2-e]pyrimidine-6,8-dicarbonitrile 
• 1375399-16-8 7-(4-chlorophenyl)-9-imino-4-oxo-3-phenyl-5,9-dihydro-4H-pyrido[1,2-a]thieno[3,2-e]pyrimidine-6,8-dicarbonitrile 
• 1375399-19-1 9-imino-4-oxo-3-phenyl-7-(thiophen-2-yl)-5,9-dihydro-4H-pyrido[1,2-a]thieno[3,2-e]pyrimidine-6,8-dicarbonitrile 
• 1375399-82-8 N-(3-cyano-4-phenylthiophen-2-yl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxamide 
• 1375399-85-1 N-(3-cyano-4-phenylthiophen-2-yl)-2-oxo-6-(thiophen-2-yl)-1,2-dihydropyridine-3-carboxamide 
• 1375399-88-4 N-(3-cyano-4-phenylthiophen-2-yl)-6-(6-methylpyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide 
• 1089976-55-5 2-cyano-N-(3-cyano-4-phenylthiophen-2-yl)acetamide 
• 1393485-07-8 2((E)-3-{4-[(Z)5-(1-dimethylaminomethylidene)-3-methyl-4-oxo-thiazolidin-(2Z)-ylideneamino]phenyl}-3-oxoprop-1-enylamino)-4-phenylthiophene-3-carbonitrile 

Relevant articles and documents

Mg/La mixed oxide as an efficient heterogeneous basic catalyst for synthesis of 2-aminothiophenes under microwave irradiation

Microwave-assisted synthesis of 2-aminothiophenes via a Gewald reaction using a heterogeneous strong basic Mg/La mixed oxide catalyst is described.

Ethylene diamine grafted nanoporous UiO-66 as an efficient basic catalyst in the multi-component synthesis of 2-aminithiophenes

This study demonstrates ED-UiO-66 as a novel and effective solid nanoporous basic catalyst prepared through the amine grafting onto the pores of UiO-66. The manufactured nanoparticles were identified by FT-IR, XRD, TGA, FESEM, TEM, CHN and BET and the characterization results certified formation of a single phase nanoporous substance with the medium grain size less than 90?nm. The synthesized material was employed as an efficient catalyst for the preparation of 2-aminotiophenes through the Gewald method. This thermochemically stable nanocatalyst was environmentally safe, reusable and economic. Therefore, this methodology can be simply extended for industrial goals.

Preparation of magnetically recyclable ZnFe2O4 nanoparticles by easy single-step co-precipitation method and their catalytic performance in the synthesis of 2-aminothiophenes

In this work, a new synthetic route for the preparation of ZnFe2O4 nanoparticles through the chemical co-precipitation using Fe2+ and Fe3+ ions in an alkaline solution was developed. The synthesized nanoparticles were characterized by XRD, FTIR, SEM, ICP-MS, DRS, TGA, VSM and elemental analysis. Characterization results confirmed the formation of single ZnFe2O4 phase, with an average particle size of 40?nm and a high saturation magnetization of 34?emu g?1. The prepared material was employed as a catalyst for the synthesis of 2-aminotiophene derivatives through the Gewald reaction. This thermally and chemically stable nanocatalyst is environmentally benign, economical and reusable which can be easily recovered using an external magnet. Therefore, it appears that this methodology can be simply extended for industrial purposes.

TiO2/nanoclinoptilolite as an efficient nanocatalyst in the synthesis of substituted 2-aminothiophenes

TiO2/nanoclinoptilolite (TiO2/NCP) was prepared by the mediation of hexadecyltrimethylammonium (HDTMA) as surfactant and used as an effective heterogeneous nanocatalyst for the preparation of substituted 2-aminotiophenes. The modified HDTMA/NCP was impregnated with titanium(IV) chloride solution followed by calcination at 500?°C for 20?h. The obtained nanocomposite was characterized using Fourier transform infrared spectroscopy, field emission scanning electron microscopy, inductively coupled plasma optical emission spectroscopy and X-ray diffraction. Moreover, the prepared nanocomposite had high stability and recoverability under mild and solvent-free conditions.