465531-76-4Relevant academic research and scientific papers
Synthesis and reactions of polymer-bound Ph3P=C=C=O: A quick route to tenuazonic acid and other optically pure 5-substituted tetramates
Schobert, Rainer,Jagusch, Carsten,Melanophy, Claire,Mullen, Gillian
, p. 3524 - 3529 (2007/10/03)
Polystyrene-bound cumulated ylide Ph3PCCO was prepared on a large scale in two steps. It reacts with Grignard compounds, amines and alcohols to give immobilized acyl, amide and ester ylides, respectively. Their Wittig reactions lead to alkenes
A new, general entry to 3,5-unsubstituted 4-O-alkyl tetramates
Paintner, Franz F.,Metz, Marcel,Bauschke, Gerd
, p. 869 - 874 (2007/10/03)
A variety of 3,5-unsubstituted 4-O-benzyl tetramates 10 was prepared in good overall yield from methyl (E)-3-benzyloxy-4-oxobut-2-enoate 7 by a reductive amination-lactamization sequence. An efficient approach to this building block as well as to various 3-alkoxy analogues is presented.
