466639-00-9Relevant academic research and scientific papers
Chemo-enzymatic synthesis of 2′,3′-dideoxy-3′-fluoro-β-D-guanosine via 2,3-dideoxy-3-fluoro-α-D-ribose 1-phosphate
Komatsu, Hironori,Araki, Tadashi
, p. 2899 - 2901 (2003)
2,3-Dideoxy-3-fluoro-α-D-ribose 1-phosphate 2 was stereoselectively synthesized and converted to 2′,3′-dideoxy-3-fluoro-β-D-guanosine 1 by enzymatic reaction using purine nucleoside phosphorylase. This chemo-enzymatic strategy was first applied to the synthesis of 1.
