46700-35-0

Upstream product

• 143-33-9 sodium cyanide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 122-04-3 4-nitro-benzoyl chloride 
• 109-77-3 malononitrile 

Downstream Products

• 180903-18-8 AB₀₅₉ 
• 180903-11-1 5-amino-1-tert-butyl-3-(4-nitrophenyl)-1H-pyrazole-4-carbonitrile 
• 5515-15-1 3-methoxy-3-(4-nitrophenyl)-2-cyanoacrylonitrile 

Relevant academic research and scientific papers

FUSED RING HETEROARYL KINASE INHIBITORS

Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states.

CHEMICAL COMPOUNDS

Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.

One-pot synthesis of tetrasubstituted pyrazoles - Proof of regiochemistry

1-Alkyl-5-amino-3-aryl-4-cyanopyrazoles, useful intermediates for fused heterocyclic systems, are synthesised by a one-pot three-step procedure from acid chlorides, malononitrile and alkylhydrazines. The regiochemistry of the hydrazine incorporation was p

Electrolytic Oxidation of Ketones in a Methanolic Solution of NaCN in the Presence of Catalytic Amounts of KI

The indirect electrolytic oxidation of ketones (1) in methanolic sodium cyanide was studied using iodide ion as a mediator.The product and the reactivity of ketone were dependent on the nature of the alkyl groups attached to the carbonyl group.Thus, 2-alk