4672-11-1

Usage

Uses

Used in Pharmaceutical Industry:
4-Piperidin-1-yl-butan-1-ol is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its presence in many drugs makes it a valuable component in the development of medications for treating depression, schizophrenia, and Parkinson's disease.
Used in Research and Development:
4-Piperidin-1-yl-butan-1-ol is utilized in research and development applications within the pharmaceutical industry. Its unique structure and properties allow scientists to explore its potential uses and interactions with other compounds, leading to the discovery of new drugs and治疗方法.

InChI:InChI=1/C9H19NO/c11-9-5-4-8-10-6-2-1-3-7-10/h11H,1-9H2

Upstream product

• 110-89-4 piperidine 
• 96-48-0 4-butanolide 
• 4753-59-7 4-Bromobutyl acetate 
• 109647-01-0 formaldehyde-[bis-(4-piperidino-butyl)-acetal] 
• 4088-34-0 1-(but-3-en-1-yl)piperidine 
• 1722-26-5 triethylamine-borane 
• 3210-08-0 4-iodo-butan-1-ol 
• 5463-76-3 γ-piperidinobutyric acid hydrochloride 
• 33036-62-3 4-Bromo-1-butanol 
• 90708-96-6 6-aza-1-boraspiro<5,5>undecane 
• 90715-64-3 4-(1-piperidyl)butylboronic acid hydrochloride 
• 6942-15-0 4-oxo-4-piperidino-butyric acid ethyl ester 
• 928-51-8 4-Chloro-1-butanol 

Downstream Products

• 99813-47-5 1-methyl-1-[4-(3,4,5-trimethoxy-benzoyloxy)-butyl]-piperidinium; iodide 
• 1001380-42-2 4-fluoro-2-nitro-5-(4-piperidin-1-ylbutoxy)-phenylamine 
• 102706-87-6 3,4,5-trimethoxy-trans-cinnamic acid-(4-piperidino-butyl ester) 
• 102700-31-2 1-(4-benzhydryloxy-butyl)-piperidine 
• 32066-01-6 3,4,5-trimethoxy-benzoic acid-(4-piperidino-butyl ester) 
• 102762-25-4 diphenyl-acetic acid-(4-piperidino-butyl ester); hydrochloride 

Relevant academic research and scientific papers

Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease

A series of phthalide alkyl tertiary amine derivatives were designed, synthesized and evaluated as potential multi-target agents against Alzheimer's disease (AD). The results indicated that almost all the compounds displayed significant AChE inhibitory and selective activities. Besides, most of the derivatives exhibited increased self-induced Aβ1-42 aggregation inhibitory activity compared to the lead compound DL-NBP, and some compounds also exerted good antioxidant activity. Specifically, compound I-8 showed the highest inhibitory potency toward AChE (IC50 = 2.66 nM), which was significantly better than Donepezil (IC50 = 26.4 nM). Moreover, molecular docking studies revealed that compound I-8 could bind to both the catalytic active site and peripheral anionic site of AChE. Furthermore, compound I-8 displayed excellent BBB permeability in vitro. Importantly, the step-down passive avoidance test indicated that I-8 significantly reversed scopolamine-induced memory deficit in mice. Collectively, these results suggested that I-8 might be a potent and selective AChE inhibitor for further anti-AD drug development.

Novel antagonists of serotonin-4 receptors: Synthesis and biological evaluation of pyrrolothienopyrazines

Based on the definition of a 5-HT4 receptor antagonist pharmacophore, a series of pyrrolo[1,2-a]thieno[3,2-e] and pyrrolo[1,2-a]thieno[2,3-e] pyrazine derivatives were designed, prepared, and evaluated to determine the properties necessary for high-affinity binding to 5-HT4 receptors. The compounds were synthesized by substituting the chlorine atom of the pyrazine ring with various N-alkyl-4-piperidinylmethanolates. They were evaluated in binding assays with [3H]GR113808 (1) as the 5-HT4 receptor radioligand. The affinity values (Ki or inhibition percentages) were affected by both the substituent on the aromatic ring and the substituent on the lateral piperidine chain. A methyl group on the tricyclic ring produced a marked increase in affinity while an N-propyl or N-butyl group gave compounds with nanomolar affinities. Among the most potent ligands, 34d was selected for further pharmacological studies and evaluated in vivo. This compound acts as an antagonist/weak partial agonist in COS-7 cells stably expressing the 5-HT4(a) receptor and is of great interest as a peripheral antinociceptive agent.

TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The invention relates to compounds of formula (I), wherein X1a, X1 to X5, Ra, Rb, n and R have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.

PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF

The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates.

Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs

Quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal anti-inflammatory drugs (NSAIDs) are disclosed. These esters and thioesters display the anti--inflammatory profile of the parent NSAIDs with greatly reduced gastrointestinal irritancy, providing a more favorable separation of therapeutic activity and toxicological side effects than the parent NSAIDs.

HYDROBORATION OF 1-(3-BUTENYL)PIPERIDINE AND 1-(4-PENTENYL)PIPERIDINE

Hydroboration of 1-(3-butenyl)- (Ia) and 1-(4-pentenyl)piperidine (Ib) with triethylamine-borane followed by hydrolysis and oxidation afforded the appropriate alcohols IIIc and IIIf resp.The spirocyclic amine-borane IIa,b isolated from the hydroboration product were transformed by hydrochloric acid into the hydrochlorides of piperidinealkylboronic acids IVa,b which were oxidized in an alkaline medium with hydrogen peroxide to the primary alcohols IIIc,f.Diethyl ester V was prepared by ethanolysis of IIa.