467426-60-4Relevant academic research and scientific papers
BuMgNiPr2: A new base for stoichiometric, position-selective deprotonation of cyclopropane carboxamides and other weak CH acids
Zhang, Mao-Xi,Eaton, Philip E.
, p. 2169 - 2171 (2002)
Using the irreversible formation of an alkane, the proton-removing ability of a magnesiated amine, and the activating effect of a carboxamido group, weakly acidic CH groups E in a variety of systems can be selectively converted into useful amido-Grignard
Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes
Shi, Yongjia,Gao, Qian,Xu, Senmiao
supporting information, p. 10599 - 10604 (2019/08/28)
We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.
