959748-73-3

Basic information

• Product Name: 2-(4-(2-hydroxyethyl)-tetrahydro-2H-pyran-4-yl)-4-methylbenzenesulfonic acid
• Synonyms: 2-(4-(2-hydroxyethyl)-tetrahydro-2H-pyran-4-yl)-4-methylbenzenesulfonic acid;2-(Tetrahydro-2H-Pyran-4-Yl)Ethyl 4-Methylbenzenesulfonate
• CAS NO: 959748-73-3
• Molecular Formula: C₁₄H₂₀O₄S
• Molecular Weight: 300.3706
• Mol File: 959748-73-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-(2-hydroxyethyl)-tetrahydro-2H-pyran-4-yl)-4-methylbenzenesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(2-hydroxyethyl)-tetrahydro-2H-pyran-4-yl)-4-methylbenzenesulfonic acid(959748-73-3)
• EPA Substance Registry System: 2-(4-(2-hydroxyethyl)-tetrahydro-2H-pyran-4-yl)-4-methylbenzenesulfonic acid(959748-73-3)

Safety Data

• Hazardous Substances Data: 959748-73-3(Hazardous Substances Data)

Upstream product

• 4677-18-3 2-(tetrahydropyran-4-yl)-ethanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 85064-61-5 2-(tetrahydro-2H-pyran-4-yl)acetic acid 

Relevant articles and documents

Pyrimidinone Derivatives as Antimalarial Agents

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

CARBOXYLIC ACID COMPOUND

[Problem] The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes. [Means for Solution] The present inventors have extensively studied a compound having a GPR40 agonistic activity, and as a result, they have found that the compound (I) of the present invention or a pharmaceutically acceptable salt thereof, in which a carboxylic acid is bonded to a bicyclic or tricyclic moiety through methylene, and further, a benzene ring substituted with a monocyclic 6-membered aromatic ring is bonded to a bicyclic or tricyclic moiety through —O-methylene or —NH-methylene, has an excellent GPR40 agonistic activity. They have also found that the compound has an excellent insulin secretion promoting action and strongly inhibits increase in the blood glucose after glucose loading, thereby completing the present invention.

TETRAZOLE COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR

Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally usefu