4679-91-8

Basic information

• Product Name: 2-benzyl-3-phenyl-1H-indole
• CAS NO: 4679-91-8
• Molecular Formula: C₂₁H₁₇N
• Molecular Weight: 283.3664
• Mol File: 4679-91-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 501.7°C at 760 mmHg
• Flash Point: 222.5°C
• Density: 1.149g/cm³
• Vapor Pressure: 1.06E-09mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 2-benzyl-3-phenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-3-phenyl-1H-indole(4679-91-8)
• EPA Substance Registry System: 2-benzyl-3-phenyl-1H-indole(4679-91-8)

Safety Data

• Hazardous Substances Data: 4679-91-8(Hazardous Substances Data)

Upstream product

• 51012-66-9 2-benzyl-2-bromoacetophenone 
• 62-53-3 aniline 
• 55520-55-3 (3R,4S)-5-Benzyl-2,3,4-triphenyl-3,4-dihydro-2H-[1,2,3]diazaphosphole 
• 74-88-4 methyl iodide 
• 102-04-5 1,3-Diphenylpropanone 
• 4980-70-5 1,3-diphenyl-1-propyne 
• 645-49-8 cis-stilben 
• 201230-82-2 carbon monoxide 
• 100-63-0 phenylhydrazine 
• 111584-85-1 1,3-diphenyl-2-(phenylamino)propan-1-one 
• 142-04-1 aniline hydrochloride 
• 32898-02-5 1,3-diphenyl-1-(phenylamino)propan-2-one 
• 1788-30-3 phenylhydrazone of dibenzyl ketone 

Downstream Products

• 103161-85-9 1-benzoyl-2-benzyl-3-phenyl-indole 

Relevant articles and documents

C2-phosphonomethyleneindole compound as well as preparation method and application thereof

The invention discloses a C2-phosphonomethyleneindole compound as well as a preparation method and application thereof. The compound provided by the invention contains an indole ring and a phosphono substituted polyfunctional compound, can be further functionalized, is an important synthetic building block in organic synthesis, and has important application value in synthesis of compounds or ligand compounds with biological activity. The raw materials used in the preparation method are simple and convenient to prepare, the reaction conditions are mild, the reaction can be directly performed inthe air atmosphere, the operation is convenient, the catalyst dosage is low, the reaction time is short, and substrate tolerance is good. In addition, the unique by-product of the preparation methodis water, so that the reaction has the advantages of higher atom economy, environment friendliness and the like.

A Convenient Modification of the Fischer Indole Synthesis with a Solid Acid

(Chemical Equation Presented). A new one-pot version of the titled reaction involves heating a mixture of a carbonyl compound, a phenylhydrazine, and the cation exchange resin Amberlite IR 120 in refluxing ethanol. A variety of enolizable aldehydes, and ketones and several substituted phenylhydrazines could thus be converted to the corresponding indoles in excellent yields (70-88%). Reaction times were typically 6-10 h, with the resin being then filtered off and the product isolated after minimal workup.

A microwave-assisted, propylphosphonic anhydride (T3P) mediated one-pot Fischer indole synthesis

A rapid, mild, and high yielding protocol for the Fischer indolization of arylhydrazines with T3P under microwave irradiation is described. Significant features of this method include short reaction times and preparative ease.