46803-98-9Relevant academic research and scientific papers
A new 'traceless' solid-phase synthesis strategy: Synthesis of a benzimidazole library
Huang, Wolin,Scarborough, Robert M.
, p. 2665 - 2668 (1999)
A new strategy to achieve 'traceless' solid-phase synthesis has been developed. Using this strategy, a 'traceless' benzimidazole library with diversity on the benzene moiety was synthesized efficiently in high yield with high purity. During the final step of this new synthetic sequence, cleavage and cyclic nucleus elaboration take place by a series of substitution and elimination reactions on the solid phase followed by release to the solution phase.
