468718-67-4Relevant academic research and scientific papers
SUBSTITUTED HETEROCYCLIC INHIBITORS OF PTPN11
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Paragraph 0375, (2019/11/19)
The present invention relates to compounds which may be useful as inhibitors of PTPN11 for the treatment or prevention of cancer and other PTP-mediated diseases. Disclosed herein are new compounds and compounds based on pyrazolopyrazines and their applica
Iridium- and rhodium-catalyzed dehydrogenative silylations of C(sp 3) - H bonds adjacent to a nitrogen atom using hydrosilanes
Mita, Tsuyoshi,Michigami, Kenichi,Sato, Yoshihiro
supporting information, p. 2970 - 2973 (2014/01/06)
Now that is just silylated: In the presence of iridium or rhodium catalysts, C(sp3) - H bonds adjacent to a nitrogen atom were silylated by the aid of a pyridine-directing group. In iridium catalysis, a hydrogen-trapping reagent such as norbornene or tert-butylethylene, which is usually required in late transition-metal-catalyzed dehydrogenative coupling reactions, was not required. In rhodium catalysis, however, 1 equivalent of COD (1,5-cyclooctadiene) was necessary to induce higher conversion. Copyright
BENZAMIDE DERIVATIVE OR SALT THEREOF
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Page/Page column 17, (2008/06/13)
There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder
Hetarynic synthesis and chemical transformation of dihydrodipyridopyrazines
Blanchard, Stéphanie,Rodriguez, Ivan,Kuehm-Caubère, Catherine,Renard, Pierre,Pfeiffer, Bruno,Guillaumet, Gérald,Caubère, Paul
, p. 3513 - 3524 (2007/10/03)
Unprecedented dihydrodipyridopyrazines were easily obtained by hetarynic dimerization of 2-alkylamino-3-halogenopyridines in the presence of the complex base NaNH2-tBuONa. Derivatizations of the new heterocycles are described. The anticancer ac
