4688-16-8

Upstream product

• 4688-15-7 (5-nitrobenzo[b]thiophen-2-yl)methanol 
• 40018-26-6 1,4-dithiane-2,5-diol 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 117000-60-9 2-acetylamino-1-(5-nitro-benzo[b]thiophen-2-yl)-ethanone 
• 20699-86-9 methyl 5-nitrobenzo[b]thiophene-2-carboxylate 
• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 
• 86010-32-4 5-Nitrobenzothiophene-2-carboxoyl Chloride 

Downstream Products

• 86010-30-2 3-cyano-4-(5-nitrobenzothienyl)-6-(p-chlorophenyl)pyridin-2-one 
• 86010-27-7 2-amino-3-cyano-4-(5-nitrobenzothienyl)-6-(p-chlorophenyl)pyridine 
• 86010-35-7 (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone 
• 86010-29-9 3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridin-2-one 
• 86010-26-6 2-amino-3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridine 

Relevant academic research and scientific papers

THERAPEUTIC USES OF INHIBITORS OF THE RNA-BINDING PROTEIN HUR

The present technology is directed to methods of treatment utilizing inhibitors of HuR interaction with RNA, where the inhibitors are of Formula I where R1 is; and X1 is OH, NH-OH, or 0-(C1-C8 unsubstituted alkyl).

HETEROARYL COMPOUNDS AS INHIBITORS OF PROGRAMMED NECROSIS PATHWAY, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to the programmed necrosis pathway.

A straightforward expeditious synthesis of 5-nitrobenzo[b]thiophene-2- carbaldehyde

A high yielding one-pot synthesis of 5-nitrobenzo[b]thiophene-2- carbaldehyde is reported using the readily available,cheap starting material 2,5-dihydroxy-1,4-dithiane and 2-chloro-5-nitrobenzaldehyde.

2-Substituted 5-Nitrobenzothiophene Derivatives with Biological Activity

5-Nitrobenzothiophene-2-carboxaldehyde (I) reacted readily with compounds having an active methylene group in basic medium to give a variety of condensation products (IVa-g). The β-benzothiophenyl acrylic acid derivative (IVa) could also be prepared by heating the aldehyde (I) with acetic anhydride in presence of anhydrous sodium acetate. Its methyl ester (Vb) yielded upon condensation with hydroxylamine hydrochloride in alkaline medium the hydroxamic acid (VI). When (I) was reacted with acetyl glycine in presence of acetic anhydride, the azalactone derivative (IVe) was obtained, which upon heating with water was hydrolyzed to (IVf). The aldehyde (I) underwent readily Cross-Aldol condensation with acetaldehyde and/or acetone in alkaline medium to give the α,β-unsaturated carbonyl compounds (IVh) and (IVi), respectively.