86010-32-4

Usage

Uses

Used in Pharmaceutical Synthesis:
5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE is used as an intermediate for the synthesis of various pharmaceuticals. Its benzothiophene-2-carbonyl chloride moiety can be incorporated into different compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE serves as an intermediate in the synthesis of agrochemicals. Its reactivity allows for the creation of new compounds with pesticidal or herbicidal properties, enhancing crop protection and yield.
Used in Organic Synthesis as a Reagent:
5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE is utilized as a reagent in organic synthesis. Its strong electrophilic nature enables it to react with a variety of nucleophiles, facilitating the formation of new chemical entities for research and development purposes.
Used in Drug Development:
Due to its versatile reactivity, 5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE has potential applications in the development of new drugs. Its ability to form various chemical entities can lead to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Development:
5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE also has potential applications in the development of new agrochemicals. Its incorporation into different chemical structures can result in the creation of innovative compounds with enhanced pesticidal or herbicidal activities, contributing to more effective agricultural practices.

InChI:InChI=1/C9H4ClNO3S/c10-9(12)8-4-5-3-6(11(13)14)1-2-7(5)15-8/h1-4H

Upstream product

• 25785-09-5 ethyl 5-nitro-2-benzo[b]thiophenecarboxylate 
• 23081-03-0 5,5'-dinitro-2,2'-disulfanediyl-bis-benzaldehyde 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 
• 82301-36-8 (2-formyl-4-nitro-phenylsulfanyl)-acetic acid 

Downstream Products

• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 
• 4688-16-8 5-Nitrobenzothiophene-2-carboxaldehyde 
• 96446-86-5 4-[(5-nitro-1-benzothien-2-yl)carbonyl]morpholine 
• 86010-30-2 3-cyano-4-(5-nitrobenzothienyl)-6-(p-chlorophenyl)pyridin-2-one 
• 86010-27-7 2-amino-3-cyano-4-(5-nitrobenzothienyl)-6-(p-chlorophenyl)pyridine 
• 86010-29-9 3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridin-2-one 
• 86010-26-6 2-amino-3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridine 
• 86010-35-7 (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone 

Relevant academic research and scientific papers

5-nitro-benzothiophene-2-formic acid and chemical synthesis method thereof

The invention relates to the technical field of benzothiophene compound production, in particular to 5-nitro-benzothiophene-2-formic acid and chemical synthesis method thereof, the method is simple and low in cost, and a solid foundation is provided for mass production and subsequent research of compound materials. The molecular structure of the 5-nitro-benzothiophene-2-formic acid is shown as a formula 1, and meanwhile, the 5-nitro-benzothiophene-2-formic acid has an activity effect of inhibiting oral tooth streptococcus mutans.

Design, synthesis, and biological evaluation of novel benzo[b]thiophene-diaryl urea derivatives as potential anticancer agents

A hybrid pharmacophore approach was applied to design and synthesize a series of benzo[b]thiophene-diaryl urea derivatives 17a–g with potential anticancer effect. In vitro antiproliferative activities of all target compounds were evaluated against HT-29 a

Synthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach

To develop inhibitors blocking VEGFR2 and the Raf/MEK/ERK mitogen-activated protein kinase signaling pathway new compounds based on sorafenib were designed, synthesized and biologically evaluated. Using de novo design method, a library of new ligands was

A straightforward expeditious synthesis of 5-nitrobenzo[b]thiophene-2- carbaldehyde

A high yielding one-pot synthesis of 5-nitrobenzo[b]thiophene-2- carbaldehyde is reported using the readily available,cheap starting material 2,5-dihydroxy-1,4-dithiane and 2-chloro-5-nitrobenzaldehyde.

Solvent-free microwave synthesis of 3-(4-benzo[b]-thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-YL-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).

2-Substituted 5-Nitrobenzothiophene Derivatives with Biological Activity

5-Nitrobenzothiophene-2-carboxaldehyde (I) reacted readily with compounds having an active methylene group in basic medium to give a variety of condensation products (IVa-g). The β-benzothiophenyl acrylic acid derivative (IVa) could also be prepared by heating the aldehyde (I) with acetic anhydride in presence of anhydrous sodium acetate. Its methyl ester (Vb) yielded upon condensation with hydroxylamine hydrochloride in alkaline medium the hydroxamic acid (VI). When (I) was reacted with acetyl glycine in presence of acetic anhydride, the azalactone derivative (IVe) was obtained, which upon heating with water was hydrolyzed to (IVf). The aldehyde (I) underwent readily Cross-Aldol condensation with acetaldehyde and/or acetone in alkaline medium to give the α,β-unsaturated carbonyl compounds (IVh) and (IVi), respectively.

Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: Synthesis and antitumour activity

A series of benzoyl and cinnamoyl nitrogen mustards tethered to different benzoheterocycles and to oligopyrroles structurally related to netropsin consisting of two pyrrole-amide units and terminating with an amidine moiety have been synthesised and a str