86010-32-4

Basic information

• Product Name: 5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE
• Synonyms: 5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE;5-Nitrobenzo[b]thiophene-2-carbonyl chloride
• CAS NO: 86010-32-4
• Molecular Formula: C₉H₄ClNO₃S
• Molecular Weight: 241.65
• Mol File: 86010-32-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 157 °C
• Boiling Point: 401.7 °C at 760 mmHg
• Flash Point: 196.7 °C
• Appearance: /
• Density: 1.597g/cm³
• Vapor Pressure: 1.16E-06mmHg at 25°C
• Refractive Index: 1.712
• CAS DataBase Reference: 5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE(86010-32-4)
• EPA Substance Registry System: 5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE(86010-32-4)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 86010-32-4(Hazardous Substances Data)

Usage

General Description

5-NITRO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE is a chemical compound with the molecular formula C8H4ClNO3S. It is a yellow solid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound is a benzothiophene derivative with a nitro group and a carbonyl chloride functional group attached to the benzene ring. It is primarily used as a reagent in organic synthesis to introduce the benzothiophene-2-carbonyl chloride moiety into various compounds. The compound is known to be a strong electrophile and reacts readily with nucleophiles, making it a useful building block in organic chemistry. Additionally, it has potential applications in the development of new drugs and agrochemicals due to its versatile reactivity.

InChI:InChI=1/C9H4ClNO3S/c10-9(12)8-4-5-3-6(11(13)14)1-2-7(5)15-8/h1-4H

Upstream product

• 23081-03-0 5,5'-dinitro-2,2'-disulfanediyl-bis-benzaldehyde 
• 25785-09-5 ethyl 5-nitro-2-benzo[b]thiophenecarboxylate 
• 82301-36-8 (2-formyl-4-nitro-phenylsulfanyl)-acetic acid 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 
• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 

Downstream Products

• 6345-55-7 5-nitrobenzo[b]thiophene-2-carboxylic acid 
• 86010-30-2 3-cyano-4-(5-nitrobenzothienyl)-6-(p-chlorophenyl)pyridin-2-one 
• 86010-27-7 2-amino-3-cyano-4-(5-nitrobenzothienyl)-6-(p-chlorophenyl)pyridine 
• 86010-29-9 3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridin-2-one 
• 86010-26-6 2-amino-3-cyano-4-(5-nitrobenzothienyl)-6-phenylpyridine 
• 86010-35-7 (Z)-3-(5-Nitro-benzo[b]thiophen-2-yl)-1-phenyl-propenone 
• 4688-16-8 5-Nitrobenzothiophene-2-carboxaldehyde 
• 96446-86-5 4-[(5-nitro-1-benzothien-2-yl)carbonyl]morpholine 

Relevant articles and documents

5-nitro-benzothiophene-2-formic acid and chemical synthesis method thereof

The invention relates to the technical field of benzothiophene compound production, in particular to 5-nitro-benzothiophene-2-formic acid and chemical synthesis method thereof, the method is simple and low in cost, and a solid foundation is provided for mass production and subsequent research of compound materials. The molecular structure of the 5-nitro-benzothiophene-2-formic acid is shown as a formula 1, and meanwhile, the 5-nitro-benzothiophene-2-formic acid has an activity effect of inhibiting oral tooth streptococcus mutans.

Synthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach

To develop inhibitors blocking VEGFR2 and the Raf/MEK/ERK mitogen-activated protein kinase signaling pathway new compounds based on sorafenib were designed, synthesized and biologically evaluated. Using de novo design method, a library of new ligands was

Solvent-free microwave synthesis of 3-(4-benzo[b]-thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-YL-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity

A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).