469-54-5

Usage

Chemical Properties

White Solid

Uses

A newly metabolite of Griseofulvin (G787500).

Upstream product

• 7647-01-0 hydrogenchloride 
• 67-56-1 methanol 
• 126-07-8 griseofulvin 
• 56-23-5 tetrachloromethane 
• 64-17-5 ethanol 
• 7732-18-5 water 

Downstream Products

• 469-51-2 (2S,6'R)-(7-chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1'-(4'-methoxy-6'-methylcyclohex-3'-ene-2'-one) 
• 126-07-8 griseofulvin 
• 115144-98-4 (2S,6'R)-7-chloro-4'-cyclohexyloxy-4,6-dimethoxy-6'-methyl-spiro[benzofuran-2,1'-cyclohex-3'-ene]-3,2'-dione 
• 26891-76-9 (2S,6'R)-(7-chloro-6-hydroxy-4-methoxybenzofuran-3-on)-2-spiro-1'-(6'-methylcyclohex-2',4'-dione) 
• 133132-28-2 (4R)-6-chloro-7,9-dimethoxy-4-methyl-3,4-dihydro-1H-dibenzofuran-2-one 
• 17793-65-6 (+)-2'-demethoxy-2',3'-dihydrogriseofulvin 
• 102003-78-1 2,4,6-triethoxy-3-chloro-benzoic acid ethyl ester 
• 3186-94-5 4,6-diethoxy-3-chloro-2-hydroxy-benzoic acid 
• 3187-20-0 3-chloro-4,6-dimethoxysalicylic acid 

Relevant academic research and scientific papers

COMPOUND USED AS AUTOPHAGY REGULATOR, AND PREPARATION METHOD THEREFOR AND USES THEREOF

It is related to compounds used as autophagy modulators and a method for preparing and using the same, specifically providing a compound of general formula (I), or pharmaceutically acceptable salts thereof, which is a type of autophagy modulators, particularly mammalian ATG8 homologues modulators.

Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.