4695-20-9Relevant academic research and scientific papers
Synthesis of thiazolidin-4-ones via [3+2] cycloaddition of in situ generated aza-oxyallylic cations with isothiocyanates
Wang, Gangqiang,Zhao, Sen,Chen, Rongxing,Yang, Liangfeng,Wang, Jian,Guo, Haibing,Wu, Minghu,Domena, Justin,Xing, Yalan,Sun, Shaofa
, p. 4308 - 4311 (2017)
A highly efficient one-pot synthesis of thiazolidin-4-ones via [3+2] cycloaddition of aza-oxyallylic cations with isothiocyanates is developed. The aza-oxyallyic cations were generated in situ in the present of a base. This cycloaddition reaction allows t
New methods for the synthesis of 2-aminothiazolones
Caille, Seb,Bercot, Eric A.,Cui, Sheng,Faul, Margaret M.
, p. 2003 - 2006 (2008/09/20)
(Chemical Equation Presented) Two new methods for the synthesis of 2-aminothiazolones from 2-(4-methoxybenzylthio)acetic acids are described. A single reagent and simple experimental conditions are used in the key tandem deprotection-cyclization process. In the first approach 2-aminothiazolones are directly accessed via cyclization of the corresponding N-acylisothioureas. The second complementary approach provides access to a variety of 2-thiomethylthiazolones via cyclization of N-acyldithioimidates. The product 2-thiomethylthiazolones are then efficiently converted to 2-aminothiazolones via amine displacement.
