93020-55-4

Basic information

• Product Name: 2-Thiazolamine, 5-methyl-N,4-diphenyl-
• CAS NO: 93020-55-4
• Molecular Formula: C16H14N2S
• Molecular Weight: 266.367
• Mol File: 93020-55-4.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, 5-methyl-N,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, 5-methyl-N,4-diphenyl-(93020-55-4)
• EPA Substance Registry System: 2-Thiazolamine, 5-methyl-N,4-diphenyl-(93020-55-4)

Safety Data

• Hazardous Substances Data: 93020-55-4(Hazardous Substances Data)

Upstream product

• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 133145-92-3 1-phenylpropan-1-one O-acetyl oxime 
• 103-72-0 phenyl isothiocyanate 
• 93-55-0 1-phenyl-propan-1-one 
• 100-47-0 benzonitrile 
• 333-20-0 potassium thioacyanate 
• 62-53-3 aniline 
• 103-85-5 monophenylthiourea 
• 21486-46-4 1-phenyl-2-thiocyanato-propan-1-one 
• 4695-20-9 2-anilino-5-methyl-thiazol-4-one 
• 87456-64-2 α-tosyloxypropiophenone 

Relevant articles and documents

α-Selective C(sp3)-H Thio/Selenocyanation of Ketones with Elemental Chalcogen

A facile method is disclosed for the synthesis of α-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.

Highly efficient heterogeneous copper-catalysed coupling of oxime acetates with isothiocyanates leading to 2-aminothiazoles

The heterogeneous coupling reaction of oxime acetates with isothiocyanates was achieved at 110°C in toluene in air in the presence of a bidentate nitrogen-functionalised MCM-41-immobilised copper(I) complex (MCM-41-2N-CuI) with Cs2CO3 as base to afford a variety of 2-aminothiazoles in good yields. The MCM-41-2N-CuI catalyst can be easily recovered by a simple filtration and reused at least eight times without significant loss of activity.

Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease

A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds that counteracted tau-induced cell toxicity at nanomolar concentrations. These congeners therefore have strong potential as possible treatment for Alzheimer's disease and other related tauopathies.