46978-41-0

Upstream product

• 52250-52-9 1-Benzyl-6-methoxy-3,4-dihydro-isoquinoline; hydrochloride 
• 20341-22-4 N-[2-(3-methoxy-phenyl)-ethyl]-2-phenyl-acetamide 
• 55-81-2 4-Methoxyphenethylamine 
• 1286209-59-3 C₁₇H₁₃NO₂ 
• 103-82-2 phenylacetic acid 

Downstream Products

• 79641-75-1 1-Benzyl-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride 
• 1286209-59-3 C₁₇H₁₃NO₂ 

Relevant academic research and scientific papers

Oxidation of 1-benzyldihydroisoquinolines or 1- benzyltetrahydroisoquinolines with dioxygen to 1-benzoylisoquinolines

An environmental-benign methodology to synthesize 1-benzoylisoquinolines from 1-benzyl-3, 4-dihydroisoquinolines or 1-benzyl-1,2,3,4- tetrahydroisoquinolines using dioxygen as an oxidant was developed. This methodology in combination with Bischler-Napieralski reaction leads to a facile synthesis of 1-benzoylisoquinolines from phenylacetic acids and phenylethanamines.

TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel acetamide derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compound

S-tetrahydroprotoberberineoxidase, process for producing the same and use thereof

The invention relates to the enzyme S-tetrahydroprotoberberineoxidase, which oxidizes selectively S-tetrahydroprotoberberines and S-1-benzyl-1,2,3,4-tetrahydroisoquinoline in the presence of oxygen, resulting in the corresponding protoberberines and 1-ben

PHOSGENATION OF BENZYLTETRAHYDROISOQUINOLINES. A NEW METHOD OF BERBINES AND BERBIN-8-ONES SYNTHESIS

A novel synthesis of the berbine ring skeleton by the way of the berbin-8-ones is reported.Treatment of 1-benzyl-1,2,3,4-tetrahydroisoquinolines 1a-d with phosgene gas gave a new series of N-chloroformyl derivatives 2a-d.Intramolecular ring closure of the