20341-22-4

Basic information

• Product Name: Benzeneacetamide, N-[2-(3-methoxyphenyl)ethyl]-
• CAS NO: 20341-22-4
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.33800
• Mol File: 20341-22-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 61-62 °C
• Boiling Point: 491.7±38.0 °C(Predicted)
• Density: 1.095±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzeneacetamide, N-[2-(3-methoxyphenyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, N-[2-(3-methoxyphenyl)ethyl]-(20341-22-4)
• EPA Substance Registry System: Benzeneacetamide, N-[2-(3-methoxyphenyl)ethyl]-(20341-22-4)

Safety Data

• Hazardous Substances Data: 20341-22-4(Hazardous Substances Data)

Upstream product

• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 5071-96-5 3-METHOXYBENZYLAMINE 
• 55-81-2 4-Methoxyphenethylamine 

Downstream Products

• 79641-75-1 1-Benzyl-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride 
• 46978-41-0 1-benzyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 52250-52-9 1-Benzyl-6-methoxy-3,4-dihydro-isoquinoline; hydrochloride 
• 46978-42-1 1-benzyl-3,4-dihydro-6-methoxyisoquinoline 

Relevant articles and documents

Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest

Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) or mitosis (M) phase of the cell cycle. Unfortunately, the same mechanisms that melanocytes possess to protect cells from DNA damage often confer resistance to drugs that derive their toxicity from S or M phase arrest. Described herein is the synthesis of a combinatorial library of potential proapoptotic agents and the subsequent identification of a class of small molecules (triphenylmethylamides, TPMAs) that arrest the growth of melanoma cells in the G1 phase of the cell cycle. Several of these TPMAs are quite potent inducers of apoptotic death in melanoma cell lines (IC50 ～ 0.5 μM), and importantly, some TPMAs are comparatively nontoxic to normal cells isolated from the bone marrow of healthy donors. Furthermore, the TPMAs were found to dramatically reduce the level of active nuclear factor κ-B (NFκB) in the cell; NFκB is known to be constitutively active in melanoma, and this activity is critical for the proliferation of melanoma cells and their evasion of apoptosis. Compounds that reduce the level of NFκB and arrest cells in the G1 phase of the cell cycle can provide insights into the biology of melanoma and may be effective antimelanoma agents.

PHOSGENATION OF BENZYLTETRAHYDROISOQUINOLINES. A NEW METHOD OF BERBINES AND BERBIN-8-ONES SYNTHESIS

A novel synthesis of the berbine ring skeleton by the way of the berbin-8-ones is reported.Treatment of 1-benzyl-1,2,3,4-tetrahydroisoquinolines 1a-d with phosgene gas gave a new series of N-chloroformyl derivatives 2a-d.Intramolecular ring closure of the

Dihydroisoquinoline rearrangement. 13. Effect of substituents in the isoquinoline frame on the rearrangement of tertiary 1,2-dihydroisoquinolines

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