20341-22-4

Upstream product

• 5071-96-5 3-METHOXYBENZYLAMINE 
• 103-80-0 phenylacetyl chloride 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 103-82-2 phenylacetic acid 
• 55-81-2 4-Methoxyphenethylamine 

Downstream Products

• 79641-75-1 1-Benzyl-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride 
• 46978-41-0 1-benzyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 52250-52-9 1-Benzyl-6-methoxy-3,4-dihydro-isoquinoline; hydrochloride 
• 46978-42-1 1-benzyl-3,4-dihydro-6-methoxyisoquinoline 

Relevant academic research and scientific papers

Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest

Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) or mitosis (M) phase of the cell cycle. Unfortunately, the same mechanisms that melanocytes possess to protect cells from DNA damage often confer resistance to drugs that derive their toxicity from S or M phase arrest. Described herein is the synthesis of a combinatorial library of potential proapoptotic agents and the subsequent identification of a class of small molecules (triphenylmethylamides, TPMAs) that arrest the growth of melanoma cells in the G1 phase of the cell cycle. Several of these TPMAs are quite potent inducers of apoptotic death in melanoma cell lines (IC50 ～ 0.5 μM), and importantly, some TPMAs are comparatively nontoxic to normal cells isolated from the bone marrow of healthy donors. Furthermore, the TPMAs were found to dramatically reduce the level of active nuclear factor κ-B (NFκB) in the cell; NFκB is known to be constitutively active in melanoma, and this activity is critical for the proliferation of melanoma cells and their evasion of apoptosis. Compounds that reduce the level of NFκB and arrest cells in the G1 phase of the cell cycle can provide insights into the biology of melanoma and may be effective antimelanoma agents.

TETRAHYDROISOQUINOLYL ACETAMIDE DERIVATIVES FOR USE AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to novel acetamide derivatives of formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compound

PHOSGENATION OF BENZYLTETRAHYDROISOQUINOLINES. A NEW METHOD OF BERBINES AND BERBIN-8-ONES SYNTHESIS

A novel synthesis of the berbine ring skeleton by the way of the berbin-8-ones is reported.Treatment of 1-benzyl-1,2,3,4-tetrahydroisoquinolines 1a-d with phosgene gas gave a new series of N-chloroformyl derivatives 2a-d.Intramolecular ring closure of the

Synthesis and Photo-oxygenation of Some Substituted 1-Benzyl-3,4-dihydroisoquinolines. Mechanism of Enamine Photo-oxygenation

The synthesis of a series of substituted 1-benzyl-3,4-dihydroisoquinolines by Bischler-Napieralski cyclization is described.Competitive methylene blue sensitized photo-oxygenation experiments allowed the determination of relative rates of photo-oxygenation of 1-benzyl-3,4-dihydroisoquinolines.Substituents were shown to affect both the equilibrium concentration of the tautomeric enamine and the overall photo-oxygenation rate.After correcting for differences in enamine concentration, the relative rate data provided a diagnostic probe of the reaction mechanism, which involves transfer of charge in the rate-limiting step.